Title: Endocrinology Review Thyroid, pituitary, adrenal
1Endocrinology ReviewThyroid, pituitary, adrenal
bone
2Basic thyroid physiology
3Hypothalamic-Pituitary-Thyroid Axis
4Thyroid hormones
From UpToDate
5Thyroid hormone transport
- Three major transport proteins
- Thyroxine-binding globulin (TBG)
- Thyroxine-binding prealbumin (TBPA)
- Albumin
- Free (unbound) hormones are active
- Proportion of free hormones
- 0.04 of T4
- 0.4 of T3
6(No Transcript)
7Thyrotoxicosis
8Clinical features of thyrotoxicosis
- Weight loss
- Increased appetite
- Heat intolerance
- Anxiety, irritability
- Fine tremor
- Fatigue
- Thyroid stare
- Systolic HTN
- Tachycardia
- Palpitations
- Atrial fibrillation
- Frequent BMs
- Proximal weakness
- Diaphoresis
- Moist skin
- Fine hair
9Thyrotoxicosis - Investigations
- Primary
- Low TSH
- Increased fT3 and/or fT4
- Thyroid uptake and scan to determine etiology of
1o hyperthyroidism - Secondary
- TSH elevated or not suppressed
- Increased fT3 and/or fT4
10Causes of 1o thyrotoxicosis
- Graves disease
- Toxic adenoma or toxic multinodular goitre
- Thyroiditis
- Jod-Basedow (iodine-induced)
- Exogenous thyroid hormone
- Gestational hyperthyroidism (hCG-induced)
11Graves disease
- Autoimmune disorder
- Thyroid stimulating immunoglobulin binds TSH
receptor - F gt M
- Any age with peak in 3rd-4th decade
- Diffusely enlarged meaty goitre
12Graves Hyperthyroidism
13Graves ophthalmopathy
14Pretibial myxedema
15Graves diseaseIncreased homogeneous uptake
16Treatment of Graves disease
- Methimazole or propylthiouracil (PTU)
- Radioactive iodine therapy
- Thyroidectomy
- Temporary measures
- ?-blockade
- Steroids (decrease T4 to T3 conversion)
- Iodine (Wolff-Chaikoff effect)
17Toxic adenoma
- Solitary thyroid nodule produces excess hormone
- Accounts for lt 5 of hyperthyroidism
- Frequency increases with age
- F gt M
- Treatment of choice radioactive iodine therapy
18Toxic adenoma
19Toxic multinodular goitre
20Toxic multinodular goitre
- ? 2 nodules producing excess hormone
- In Canada, most patients are gt 50 yrs old
- Younger patients in areas of iodine deficiency
- Compressive symptoms can occur
- Treatment of choice I-131
21Toxic multinodular goitre
22Thyroiditis
- Destruction of thyroid cells causes release of
hormones - Autoimmune, infectious and toxic causes
- Can occur in post-partum period
- Can be associated with fever, painful tender
gland
23Diagnosis treatment of thyroiditis
- Low uptake on thyroid scan
- NSAIDs for painful inflammation
- ?-blockers to control symptoms
- Steroids for severe cases
- Often followed by hypothyroid phase
24Gestational hyperthyroidism
- hCG mimics TSH and stimulates thyroid hormone
production - Associated with hyperemesis gravidarum, multiple
gestation - Improves by 2nd trimester
- Must differentiate from Graves disease
- ?-blocker PTU can be used during pregnancy
25Extrathyroidal sources of thyroid hormone
- Exogenous sources
- Exogenous thyroid hormone
- Hamburger thyrotoxicosis
- Endogenous sources
- Struma ovarii
- Functioning thyroid cancer
26Other causes of hyperthyroidism
- TSH-secreting tumour
- Iodine load (Jod-Basedow phenomenon)
- Pituitary resistance to thyroid hormone
27Hypothyroidism
28Hypothyroidism
- 2-3 of population
- FM 101
- 1o hypothyroidism (90)
- Autoimmune (e.g., Hashimotos)
- Iatrogenic (surgery, RAI, drugs, iodine)
- Congenital, intrinsic defect of hormone synthesis
- Infiltrative (amyloid, progressive systemic
sclerosis) - 2o hypothyroidism - TSH deficiency
- 3o hypothyroidism - TRH deficiency
29Clinical features of hypothyroidism
- Fatigue
- Cold intolerance
- Slow mental physical performance
- Hoarse voice
- Bradycardia
- Diastolic hypertension
- Edema
- Weight gain
- Constipation
- Menorrhagia
- Dry skin
- Macroglossia
- Muscle cramps
- Delayed DTR
- Dyslipidemia
30Hypothyroidism - Lab tests
- 1o hypothyroidism
- Elevated TSH
- Low fT4 and/or fT3
- Central hypothyroidism
- Low fT4 and/or fT3
- TSH not reliable
31Treatment of hypothyroidism
- Typical levothyroxine (LT4) dose 50 - 200 mcg
- Start low dose (25 mcg) and titrate up slowly in
elderly - R/O adrenal insufficiency
- Check TSH 6-8 wk after dose change titrate to
normalize TSH for 1o hypothyroidism - Titrate to normalize fT3 for central
hypothyroidism
32Myxedema coma
- Severe hypothyroidism
- Precipitating event (e.g., trauma, sepsis, cold
exposure, MI, narcotics) - Clinical features Hypothermia, hypoglycemia,
hypotension, bradycardia, hypoventilation - Mortality up to 60
- Treatment
- ABCs
- Stress-dose steroids
- L-T4 0.2-0.5 mg IV then 0.1 mg daily
33Non-thyroidal illnessSick euthyroid syndrome
34Non-thyroidal illness
- Change in thyroid hormone levels related to
serious illness - Abnormalities in TSH secretion, hormone binding
metabolism - Decreased T4 to T3 conversion
- Typically see low fT3 high rT3
- More severe illness fT3, fT4 TSH can all be
low - Rx Treat underlying illness
35Thyroid nodules and malignancies
36Thyroid nodules
- 4 prevalence
- 5 malignant
- If nodule is identified, check TSH
- Low TSH ? Thyroid scan
- Low probability of malignancy with hot nodules
- FNAB if cold nodule is present (15-20 malignant)
- Normal or high TSH ? FNAB if palpable or gt 1 cm
in diameter
37Thyroid malignancies
- Well-differentiated thyroid carcinomas
- Papillary
- Follicular
- Medullary thyroid carcinoma
- Familial forms MEN IIa IIb, familial
medullary carcinoma - Calcitonin is a tumour marker
- Anaplastic thyroid carcinoma
- Very poor prognosis
38Well-differentiated thyroid carcinoma
- Total thyroidectomy
- I-131 therapy if higher risk
- Multifocal
- Large tumour
- Capsular invasion
- Lymph node or distant metastases
- TSH suppression
- Follow thyroglobulin level
39Medullary thyroid CA
- Look for other features of MEN IIa IIb
- R/O pheochromocytoma
- R/O 1o hyperparathyroidism
- RET protooncogene mutation
- Treatment
- Surgical resection for cure
- Some respond to MIBG or octreotide
- Prophylactic thyroidectomy in affected relatives
40MEN syndromes
MEN 1 MEN 2A MEN 2B
Parathyroid adenoma Enteropancreatic tumour Foregut carcinoid Anterior pituitary tumour Adrenal cortex Medullary thyroid cancer Pheochromo-cytoma Parathyroid tumours Cutaneous lichen amyloidosis Medullary thyroid cancer Pheochromo-cytoma Marfanoid habitus Mucosal neuromas
41Medullary thyroid CA
- Look for other features of MEN IIa IIb
- R/O pheochromocytoma
- R/O 1o hyperparathyroidism
- RET proto-oncogene mutation
- Treatment
- Surgical resection for cure
- Some respond to MIBG or octreotide
- Prophylactic thyroidectomy in affected relatives
42Pituitary - Adrenal Disorders
43Basic pituitary adrenal physiology
44Hypothalamic anterior pituitary hormones
- GHRH ? Growth hormone (GH)
- TRH ??TSH
- Somatostatin ? ? GH TSH
- TRH Prolactin-releasing factors ? Prolactin
- Dopamine ? ? Prolactin
- CRH ? ACTH
- GnRH ? LH FSH
45Pituitary hormones
- Anterior
- Growth hormone
- ACTH
- LH
- FSH
- TSH
- Prolactin
- Posterior
- ADH (arginine vasopressin)
- Oxytocin
46Hyperprolactinemia
47Causes of hyperprolactinemia
Physiologic Medications Pathologic
Pregnancy Nipple stimulation Sleep Stress Exercise Estrogen Anti-psychotics MAOI Opioids Cimetidine Licorice Pituitary tumours Stalk compression Chest wall lesions Hypothyroidism Renal failure Severe liver disease
48Hyperprolactinemia
- Clinical features
- Galactorrhea, gynecomastia, infertility, low bone
density - Headaches, bitemporal hemianopsia (if
macroadenoma affects optic chiasm) - Treat underlying cause, if present
- 1o Rx for prolactinoma
- Dopamine agonist (e.g., bromocriptine or
cabergoline)
49Acromegaly
50Clinical features of acromegaly
- Coarse facial features
- Acral enlargement
- Hyperhidrosis
- Heat intolerance
- Oily skin
- Fatigue
- Weight gain
- HTN
- Goitre
- Cardiomegaly
- Insulin resistance
- Arthralgias
- Parasthesias
- Hypogonadism
- Headaches
51Acromegaly
- Diagnostic tests
- Glucose suppression test
- IGF-1 level
- Treatment
- Surgery
- Somatostatin analogues (Octreotide)
- Radiotherapy
- GH receptor antagonist (Pegvisomant)
52Posterior pituitary disorders
53SIADH Diagnostic criteria
- Plasma osmolality lt 275 mOsm/kg H2O, excluding
pseudohyponatremia or hyperglycemia - Inappropriate urine concentration (UOsm gt 100
with normal renal function) - Clinical euvolemia
- Elevated urine sodium excretion with normal salt
and water intake - Absence of other potential causes of euvolemic
hypo-osmolality (hypothyroidism, adrenal
insufficiency, diuretic use)
54Treating SIADH
- Fluid restriction
- Loop diuretics
- Hypertonic saline if urgent correction needed
- Demeclocycline, lithium (rarely used)
- Do not correct Na too quickly
- Treat underlying cause
55Diabetes insipidus
- Clinical features
- Polyuria, polydispsia
- Hypernatremia, dehydration
- Low urine Na osmolality
- Treatments
- Oral IV fluids
- dDAVP
- For nephrogenic DI
- Na restriction, thiazides PG inhibitors
56Hypothalamic Pituitary Adrenal Axis
From Williams Textbook of Endocrinology
57POMC synthesis and cleavage
From Williams Textbook of Endocrinology
58Retroperitoneal Anatomy
59Microscopic anatomy
Zone Hormone
Glomerulosa Aldosterone
Fasciculata Cortisol
Reticularis Androgens
Medulla Catecholamines
From Williams Textbook of Endocrinology
60Adrenal steroid function
- Glucocorticoids
- Affects fuel metabolism, responses to injury and
general cell function - Mineralocorticoids
- Control body Na and K content
- Androgens
- Similar function to male gonadal hormones
61Adrenal steroidogenesis
From Williams Textbook of Endocrinology
62Sites of glucocorticoid action
From Williams Textbook of Endocrinology
63Cushings syndrome
64Features of Cushings
- Moon facies
- Facial plethora
- Dorsal supraclavicular fat pads
- Mental status change
- HTN
- Visceral adiposity
- Muscle wasting
- Ecchymoses
- Thin skin
- Purple striae
- Osteoporosis
- Avascular necrosis
- Insulin resistance
65Screening tests for Cushings syndrome
- 24 hr urinary free cortisol
- Low-dose dexamethasone suppression test
- Evening cortisol
- Salivary cortisol (2300)
66Working up Cushings
Diagnose Cushings
ACTH gt 2
ACTH lt 2
High-dose DST
Adrenal Imaging
Ectopic Cushings or Cushings disease
Cushings disease
Adrenalectomy
MRI Pituitary
Inferior petrosal sinus sampling
Pituitary surgery
Cushings disease
Ectopic Cushings
CT Chest/abdo Octreotide scan
MRI Pituitary
Pituitary surgery
67Adrenal insufficiency
68Clinical features of adrenal insufficiency
- Addisons
- Hyperpigmentation
- Volume depletion
- N/V, abdo pain
- Hyperkalemia
- Weight loss
- Fatigue
- Weakness
- Hypoglycemia
- Hyponatremia
- Anemia
69Adrenal insufficiency
- Treatment
- IV fluids
- Glucocorticoid therapy
- Mineralocorticoid therapy for Addisons
- Diagnosis
- ACTH stimulation test
- Insulin tolerance test for central disease
70Primary hyperaldosteronism
71Aldosterone secretion action
Hypotension Low Na
Renin
Angiotensinogen Angiotensin I
Aldosterone
ACE
Angiotensin II
? Na reabsorption
? Blood pressure
72Control of renin secretion
- Promoters
- Low perfusion pressure
- Low tubular Na
- Hemorrhage
- Renal artery stenosis
- Dehydration
- Salt loss
- Hyperkalemia
- Norepinephrine
- Suppressors
- High-salt diet
- Elevated BP
- Hypokalemia
- Beta-blockers
- Indomethacin
73Assessment of renin-angiotensin-aldosterone axis
- Random plasma renin activity not reliable
- Plasma aldosterone gt 695 pmol/L
- Aldosteronerenin ratio
- 24 hr urinary aldosterone
- Normal 14-56 nmol
- Aldosterone-producing adenoma 125 ? 9 nmol
- Idiopathic hyperaldosteronism 75 ? 5 nmol
- Adrenal vein sampling
74From UpToDate
75Adrenal androgens
76Adrenal androgen secretion
- gt 50 of circulating androgens in premenopausal
females - Relative contribution smaller in males
- Stimulated by ACTH
- DHEA and androstenedione levels demonstrate
circadian rhythm (but not DHEAS)
77Congenital adrenal hyperplasia
X
X
78Congenital adrenal hyperplasia
- Autosomal recessive disorder
- Presentations of CAH
- Female neonates Ambiguous genitalia
- Male neonates Adrenal crisis
- Non-classic Hirsutism infertility in females
- Treatment
- Glucocorticoid therapy
- Mineralocorticoid for salt-wasting varieties
79Pheochromocytoma
80Clinical features of pheochromocytoma
- Paroxysmal or sustained HTN
- Triad H/A, palpitations/tachycardia,
diaphoresis - Postural drop in BP
- Dilated cardiomyopathy
- Tremor, anxiety
- Chest pain
- Papilledema, blurry vision
81Pheochromocytoma
- Diagnosis
- Urine metanephrines or plasma catecholamines
- MIBG, octreotide scan
- Treatment
- ?-blockade or CCB (not ?-blocker 1st!)
- Volume restoration
- Adrenalectomy
82Bone calcium disorders
83PTH-Ca2 feedback loop
-
Parathyroid glands
PTH
PTH
-
GI Tract
1,25 D
Ca2
Ca2
Ca2
-
ECF Ca2
84Vitamin D
7-dehydrocholesterol
Cholecalciferol
25-OH vitamin D
PTH
Calcitriol
24,25(OH)2 - D
?Intestinal Ca PO4 absorption
Multiple effects in bone
Effects in muscle
85Hypercalcemia
86Clinical manifestations of hypercalcemia
- General Weakness
- CVS HTN, valve arterial calcification
- GI Constipation, anorexia, N/V, pancreatitis
- Renal Stones, DI (polyuria), renal
insufficiency - MSK Bone pain
- CNS Altered mental status
87Mechanisms for hypercalcemia
- Increased bone resorption
- Increased gastrointestinal absorption of calcium
- Decreased renal excretion of calcium
88Increased bone resorption
- Hyperparathyroidism (usually 1o)
- Malignancies
- PTHrP (solid tumours, leukemia)
- 1,25(OH)2D (lymphomas)
- Ectopic PTH (rare)
- Osteolytic lesions
- Hyperthyroidism
- Immobilization
- Pagets disease (usually with immobilization)
- Estrogen, tamoxifen
- Hypervitaminosis A
89More causes of hypercalcemia
- Increased calcium absorption
- Increased calcium intake
- Hypervitaminosis D
- Lithium
- Thiazide diuretics
- Pheochromocytoma
- Adrenal insufficiency
- Rhabdomyolysis
- Theophylline
- Familial hypocalciuric hypercalcemia
90Ways to lower calcium
- IV fluids
- Furosemide
- Calcitonin
- Steroids
- Bisphosphonates
- Dialysis
91Management Increase Renal Excretion of Calcium
- IV fluids
- NS 200-300 cc/hr or as tolerated
- Maintain urine output 100-150 cc/hr
- Furosemide IV q4-6h
- Start when volume replete
- Watch for and correct hypomagnesemia, hypokalemia
92Management Inhibit bone resorption
- Calcitonin
- Decreases Ca by up to 0.3-0.5 mmol/L in 4-6 hrs
- Efficacy limited to first 48 hours
- Most effective in cases assoc. with
hyperphosphatemia - Indicated when volume and diuretics ineffective
- Bisphosphonates
- Pamidronate 30-90 mg IV
- Zolendronate 4 mg IV most effective for
malignancy - Works in 2-4 days
- Gallium nitrate
- 200 mg/day IV by continuous infusion over 5 days
- Potentially nephrotoxic
93Management Decrease intestinal calcium
absorption
- Glucocorticoids
- Hydrocortisone 3-5mg/kg/day IV or prednisone
20-40 mg/day - Effective for breast CA, myeloma, sarcoidosis,
vit D intoxication - Decrease calcitriol production by activated
mononuclear cells - Effect occurs in 48-72 hours
- Oral phosphate binds calcium in GI tract
94Other management strategies
- Chelators
- EDTA
- IV phosphate
- Not used due to toxicity
- Hemodialysis or peritoneal dialysis
95Hypocalcemia
96Clinical features of hypocalcemia
- Paresthesia
- Laryngospasm
- Seizures
- Carpopedal spasm
- Chvosteks sign (CN VII)
- Trousseaus sign (carpal spasm)
- Hyperreflexia
- Mental status changes
97Causes of hypocalcemia
- Low PTH
- Hypoparathyroidism
- Hypomagnesemia
- Vitamin D related
- Vitamin D deficiency
- 1?-hydroxylase activity (renal failure, vit D
dependent rickets) - Vitamin D resistant rickets
- Pseudohypoparathyroidism (PTH resistance)
- Drugs (calcitonin, furosemide)
98Treatment of hypocalcemia
- ABCs
- Replace calcium
- Calcium gluconate IV
- Oral calcium
- Treat hypomagnesemia, if present
- May require vitamin D
- Correct underlying cause
99Osteoporosis
100What is osteoporosis?
- Systemic skeletal disorder
- Characterized by compromised bone strength
- Leads to enhanced bone fragility and a consequent
increase in fracture risk
101What determines bone strength?
- Bone density
- Expressed in grams of bone mass over area or
volume of bone - Determined by peak bone mass amount of bone
loss - Bone quality
- Refers to architecture, damage accumulation
(e.g., microfractures) mineralization
NIH Consensus Statement 2000
102Bone density quality determine bone strength
Normal bone Low BMD Poor
quality
103Osteoporosis fractures
- Osteoporosis is a significant risk factor for
fractures - Fractures occur when a failure-inducing force is
applied to osteoporotic bone
104Indications for BMD 50 yrs
- Age 65 yrs
- Fragility fracture after age 40 yr
- Prolonged glucocorticoid use
- Use of other high-risk medications
- Parental hip fracture
- Vertebral or osteopenia on X-ray
- Current smoking or high EtOH intake
- Low weight (lt 60kg) or wt loss (gt10 of weight at
age 25 yr) - Rheumatoid arthritis
- Other disorder strongly associated with
osteoporosis
CMAJ 2010
105Indications for BMD lt 50 yrs
- Fragility fracture
- Prolonged use of glucocorticoid
- Use of other high-risk medication
- Hypogonadism or premature ovarian failure
- Malabsorption syndrome
- Primary hyperparathyroidism
- Disorder strongly associated with rapid bone loss
and/or fracture
CMAJ 2010
106DEXA is used to measure BMD
- The PROS of DEXA scanning
- Quick, non-invasive
- 1/10 radiation of CXR (background radiation
exposure over 1 day) - Most accurate estimator of fracture risk
- The CONS of DEXA scanning
- Not a measure of bone strength (only accounts for
70 of strength) - Inter-operator variability, lack of
standardization
107Who should be screened?
- Indications for BMD scan
- Patients with 1 major or 2 minor risk factors for
osteoporosis - Age 65 years regardless of risk factors
- Contraindications for BMD scan
- Pregnancy
- Recent GI study or nuclear medicine test (wait at
least 72 hr up to 7 d for long-lived isotopes
like gallium)
108Interpretation of BMD measurements
- T-score of SDs from average person of same
gender at peak bone mass - Z-score of SDs compared to average person of
same gender, age race
109WHO diagnostic categories
Classification Criterion
Normal T-score - 1.0
Osteopenia T-score between -1.0 and -2.5
Osteoporosis T-score lt -2.5
Severe osteoporosis T-score lt -2.5 with Hx of fragility fracture(s)
110Secondary causes of osteoporosis
Endocrine Metabolic Nutritional Drugs Collagen disorders Other
Hypogonadism Cushings Thyrotoxicosis Anorexia nervosa Hyperprolactinemia Porphyria Hypophosphatemia Diabetes Pregnancy Hyperparathyroidism Acromegaly Malabsorption Malnutrition Chronic cholestatic liver disease Gastric operations Vitamin D deficiency Calcium deficiency Alcoholism Glucocorticoids Excessive thyroid hormone Heparin GnRH agonists Phenytoin Phenobarbital Vitamin D toxicity Osteogenesis imperfecta Homocystinuria Ehlers-Danlos syndrome Marfan syndrome Rheumatoid arthritis Myeloma some cancers Immobilization Renal tubular acidosis Hypercalciuria COPD Organ transplantation Mastocytosis Thalassemia
111Calcium vitamin D intake
Calcium Calcium
Children (4-8) 800 mg
Adolescents (9-18) 1300 mg
Premenopausal women 1000 mg
Men lt50 1000 mg
Menopausal women 1500 mg
Men gt 50 1500 mg
Pregnant or lactating women 1000 mg
Vitamin D Vitamin D
Age lt 50 400 IU
Age gt 50 800 IU
112Fall Prevention
- Risk Factors
- Sedatives
- Previous fall
- Cognitive impairment
- Visual impairment
- Foot problems
- Gait abnormalities
- Lower extremity disability
- Prevention measures
- Bathroom lights on
- Install grab bars
- Avoid loose rugs
- Remove clutter
- Keep wires behind furniture
113Who should receive pharmacotherapy?
11410-yr fracture probability
Probability ()
T-score
Age (yrs)
Osteoporos Int 2001 12 989
115FRAX Calculation tool
116FRAX Calculation tool
117Treat high risk patients
- gt 20 10-yr fracture risk
- Prior fragility of hip
- Fragility of spine
- gt 1 fragility
CMAJ 2010
118Moderate risk (10-20 10-yr risk)
- Consider treatment if
- Prior wrist and age gt 65 yr
- L-spine T-score ltlt femoral neck
- Rapid bone loss
- Androgen deprivation therapy or aromatase
inhibitor - Long-term or repeated glucocorticoid use
- Recurrent falls (gt 2 in 12 mos)
- Disorder strongly associated with osteoporosis or
rapid bone loss
CMAJ 2010
119Bisphosphonates
- Similar in structure to pyrophosphate in bone
- Attaches to bone surface and inhibits
osteoclastic resorption - PO Alendronate, risedronate
- IV Pamidronate, zoledronic acid
- Possible adverse effects Reflux, ONJ, atrial
fibrillation, low-energy subtrochanteric fractures
120Denosumab (Prolia)
- Human monoclonal RANKL antibody
- Inhibits osteoclastic activity
- Pros
- Convenient, 60 mg SC q6 mos
- Reduces vertebral non-vertebral s
- Well-tolerated
- Cons
- Lack of long-term data
- Dermatologic side effects
121Calcitonin
- Inhibits bone resorption
- Analgesic effect
- No drug-drug interactions
- Well-tolerated
- Evidence for reduction in vertebral fractures,
but not non-vertebral fractures
122Hormone replacement therapy
- The benefits
- Decreases osteoclastic activity
- Increases BMD lowers fracture risk
- Treats symptoms of estrogen deficiency
- Decreases colon cancer risk
- The down side
- Increased CVD, VTE PE risk
- Increased breast cancer risk
- Adverse effect on cognition
123Selective Estrogen Receptor Modulator (SERM)
- Binds to estrogen receptors
- Produces an estrogen agonist effect in some
tissues - Produces an estrogen antagonist effect in others
- Examples Tamoxifen, raloxifene
124Guidelines for Teriparatide
- 1st line Rx for women 65 yrs with T lt -2.5 and
Hx of vertebral fracture - Preferable to treat bisphosphonate naïve patients
- Consider treating post-menopausal women with T lt
-3.5 who continue to fracture despite adequate (2
yr) trial of therapy - Discontinue bisphosphonate prior to PTH
- Limit PTH Rx to maximum 24 mos
- Administer bisphosphonate therapy after PTH course
CMAJ 2006 17548
125Hip protectors
- 1801 frail but ambulatory elderly adults, mean
age 82 yrs - Hip protector control 1 2
- 1 month F/U
- Relative hazard of hip fracture 0.4 P0.008
NEJM 2000 343 1506
126Vertebroplasty kyphoplasty
- Vertebroplasty minimally invasive surgical
procedure to relieve the pain of compression
fractures - Kyphoplasty proprietary derivative procedure
using polymethylmethacrylate (PMMA) to fix a
vertebral body in place after balloon inflation
of the body
127Good luck!