Role of Chemotherapy in the Current Treatment Paradigm for Men With CRPC

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Role of Chemotherapy in the Current Treatment
Paradigm for Men With CRPC
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CRPCHow do you decide who gets chemotherapy
these days?
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Who Should Get Chemotherapy?Patients with
disease that is rapidly progressing, which may be
less sensitive to androgen blockade.
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Second-line ChemotherapyAdverse Effects Issues
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ChemotherapyAvoiding Undue Toxicity
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ChemotherapyFailure of Adding Targeted Agents
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Targeted Agents ChemotherapyPotential
Scheduling Problems
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Targeted Agents ChemotherapyBetter preclinical
data are needed to design the next round of
trials!
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Retreatment With ChemotherapyIt is feasible in a
selected group of patients who responded
initially.
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Manipulating Hormone TherapyIs it possible to
safely make the disease more chemo-sensitive?
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Radium-223Where does it fit in relation to
chemotherapy?
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Ra-223 Before Chemotherapy or in Combination
With Other Agents?Because Ra-223 does not induce
bone marrow toxicity, this possibility needs to
be tested in clinical trials.
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Should Chemotherapy Be Moved Earlier in the
Course of Disease?Currently, chemotherapy should
not be given outside the metastatic
castration-resistant setting!
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