The Role of Aldosterone, Angiotensinogen, Angiotensin I, and Angiotensin II in Renal Regulation of Water and Sodium

1
The Role of Aldosterone, Angiotensinogen,
Angiotensin I, and Angiotensin II in Renal
Regulationof Water and Sodium

• Be Sure to Watch this in the Slide Show Mode

2
Sensors in afferent arterioles detect Decreased
sodium concentration
Stimulates secretion of RENIN from
juxtaglomerular complex
Angiotensin Converting Enzyme
Renin
Renin substrate (angiotensinogen)
Angiotensin I
Angiotensin II
ANGIOTENSIN II
This is where ACE Inhibitors work to reduce
blood pressure in Hypertensive patients
Variable Vasoconstriction
Stimulates adrenal cortex To secrete ALDOSTERONE
(Possibly) directly enhances active reabsorption
of Na from distal convoluted tubule
Low Blood Volume
Aldosterone increases reabsorption of Na from
renal tubules
Blood Volume Normal or High
Angiotensin II Constricts afferent Arterioles
Angiotensin II constricts efferent arterioles
Increases serum Na concentration
Decreases Glomerular Blood Flow
The role of aldosterone, renin substrate
(angiotensinogen), angiotensin I,
angiotensin II in the renal regulation of water
sodium
Increases GFR
Decreases GFR
Allows fluid to be removed Increases the
RELATIVE concentration of Na in the blood
Incr. Tubular reabsorption of Na Cl in
ascending loop of Henle
Incr. serum Na level without further decrease of
blood volume