T-Cell%20Receptor

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T-Cell Receptor

• T-Cell Maturation,
• Activation, Differentiation

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T-Cell Receptor
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TCR Vs BCR

• T-cell receptor is membrane bound
• T-cell receptors are specific for antigen
  combined with MHC (MHC restriction)
• T-cell receptor is associated on the membrane
  with a CD3

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T-Cell Maturation,Activation, Differentiation
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T Helper and T Cytotoxic
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T-Cell Maturation
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T Cell Activation
T Helper
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T Helper
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Lineage plasticity

• Interestingly, TH1 and TH2 cells do not seem able
  to adopt TH17 or iTreg characteristics. On the
  other hand, TH17 and iTreg cells are more
  flexible and can adopt the cytokine expression
  profiles of other subsets, including TH1 and TH2
• The TH17 subset may be the most unstable or
  plastic lineage and can be induced to express
  IFN- and IL-4, depending on environmental input.

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Negative regulator
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T Cytotoxic
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NKC