Viral Replication

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Viral Replication Genetics
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INTRODUCTION

• Few genes
• or enzymes for replication
• Dependent on host

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Adsorption or Attachment

• Virus Receptor binding protein
• Host cell Corresponding receptor

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ADSORPTION
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Internalization (Penetration or Entry)

• Fusion
  
• Endocytosis (Viropexis)
• Translocation

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Fusion with host membrane
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Endocytosis enveloped virus
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Host Cell Cytoplasm
1. Adsorption
2. Penetration
Nucleus
3. Duplication/Synthesis
New spikes
New capsomers
4. Assembly
New RNA
5. Release
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Uncoating Remove the coat protein
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Formation of viral mRNAs

• DNA viruses All multiply in N Except Poxvirus
• RNA viruses All multiply in C EXCEPT few
• viruses rabies influenza

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Assembly

• Nucleus Adenovirus
• Cytoplasm Poxvirus
• Plasma membrane Influenza

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Viral Release

• Cell lyses
• Budding
• Fusion Cell-to-Cell spread

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Virus life cycle-Animation