Molly

1
Molly a newly popular club drug
2
Molly may refer to 2 different drugs

• 1. MMDA, the main constituent of Ecstasy
• 2. TFMPP, a non-controlled synthetic drug with
  properties similar to Ecstasy, often mixed with
  other drugs

3
TFMPP

• 1-(3-Trifluoromethylphenyl) piperazine
• AKA Legal E, Legal X or A2
• An off white powder sold in gelatin capsules,
  often mixed with other drugs, esp. BZP
  (benzylpiperazine)
• Popular among HS and College students attending
  Rave Parties
• Escalating abuse since 2004 when no longer
  controlled under CSA

4
TFMPP Pharmacology

• Serotonin releasing agent (like MMDA)
• Mild and mellow high
• Mild halluinogen
• Anti-aggressive
• Locomotor inhibition
• Hyperthermia
• Repiratory depression

5
However TFMPP seldom sold alone!

• Usually mixed with BZP (benzylpiperazine) for its
  norepinephrine and dopinergic effects.
• TFMPP BZP combo has norepi dopinergic
  serotonin like effects, similar to MMDA
• Marketed as a legal Ecstasy
• However BZP is controlled under CSA

6
TFMPP BZP Side Effects

• Tachycardia, hypertension
• Insomnia, anxiety
• Nausea and vomiting
• Headaches, myalgia, hangover
• Palpitations and agitation
• Seizures (including status)
• Rhabdomyolysis, renal failure

7
Psychosis

• Uncommon
• More related to BZP than TFMPP
• Amphetamine psychosis manifested by
  hallucinations, delusions and paranoia
• Symptoms usually disappear after a few weeks.

8
Treatment

• Supportive
• Benzodiazepines
• Treat seizures unresponsive to benzodiazepines
  with phenobarbital

9
References

• http//www.deadiversion.usdoj.gov/drugs_concern/tf
  mpp.pdf
• http//informahealthcare.com/doi/abs/10.3109/15563
  650.2011.572076
• http//journal.nzma.org.nz/journal/118-1227/1784/
• http//www.toxinz.co.nz/Demo/6/TjA2QkFYWDEwLzAyOA
  3D3DsecrefID0EU6DI
• http//www.partyade.com/info.php
• http//journal.nzma.org.nz/journal/122-1303/3794/