DNA Damage

1
Gene
Function
Role
DNA Damage
PRKDC DNA-PK catalytic subunit DNA Damage
Signalling GADD45A CDK Binding DNA Damage
Response CIB1 Unknown DNA end joining MSH2 DNA
Mismatch Recognition Mismatch Repair XRCC5 DNA
Helicase Non-homologous end joining
Metabolism
NDUFV2 Oxidoreductase Electron
Transport TYMS dTMP synthetase Nucleotide
Metabolism GOT2 Transaminase Amino Acid
Metabolism GSTM3 Glutathione S-transferase Xenobi
otic Metabolism GLB1 Galactosidase Ganglioside
Metabolism NDUFS1 Oxidoreductase Electron
Transport MAT2A AdoMet Synthesis Methionine
Metabolism GLO1 Glyoxalase Glutathionine
Metabolism GPX4 Peroxidase Hydrogen Peroxide
Protection ALDOC Fructose Aldolase Carbohydrate
Metabolism BLVRA Biliverdin Reductase Redox
Cycle ACADS Acyl-coenzyme A dehydrogenase Fatty
Acid Metabolism GSTZ1 Glutathione
S-transferase Amino Acid Catabolism ALDOC Aldolas
e Glycolysis
Apoptosis
SIAH2 E3 Ligase Apoptosis BCL2L1 Bcl-2 family
member Anti-Apoptotic DNASE1L3 DNAse DNA
Cleavage CASP4 Caspase Pro-Apoptotic SIVA TNFR
family member Pro-Apoptotic
Cell Signalling
CREM Transcription Factor cAMP
Signalling RREB1 Transcription Factor MAPK
Signalling MAPK1 Mitogen Signalling MAPK
Signalling GRB10 Mitogen Signalling Growth
Factor Signalling MAP2K1 Mitogen
Signalling MAPK Signalling RAB3A Ras
Associated Signalling CTNND2 Cadherin
Signalling Signalling PIK3CB inositide
kinase Mitogen Signalling RANBP1 RAN
Binding Signalling GNB1 G-Protein Signalling I
FNAR2 Inteferon Receptor JAK/STAT
Signalling NOTCH4 Notch Signalling Signalling
Sub-Polysome
Polysome
Table S1 mRNAs Upregulated during TRAIL induced
apoptosis