Coronary Phantom Design for K-edge Angiography

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Coronary Phantom Design for K-edge Angiography

• John Jorgensen
• Sarah Pachtman
• Punam Patel
• Marcus Spallek
• Advisor Dr. Frank Carroll

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MXI Systems

• MX 200
• Applications
• Radiotherapy
• Crystallography
• Mammography
• Pediatrics
• K-edge Imaging
• Angiography???

http//www.onlinetelemedicine.com/html/product/sam
_images/Angiography.jpg
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Project Background

• Monochromatic tunable X-ray
• Reduced radiation dose to patient
• Reduced contrast agent concentrations
• K-edge imaging

Diagram of MX200s laser paths and major
elements. http//www.mxisystems.com/mx200.html
FOR MORE INFO...
Free Electron Laser Laboratory ?
http//www.vanderbilt.edu/fel/
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K-edge Effect
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Project Goals

• Design a coronary phantom
• Test contrast agent concentrations
• hypersensitivity reaction to iodine (3-12
  patients)
• current clinical dilution is 116
• using monochromatic plain films it is possible to
  see 1256 dilutions
• Determine optimal angle for stereo imaging

Tan ? 3/30 0.10 ? 6
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?
30
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Solution Description

• Radio Translucent at 35 keV
• Flexible material
• Fluid perfusion
• Phantom Size
• 7.5cm diameter
• Vasculature
• Size Range 5 - 1 mm
• Coronary arteries on surface
• Curved channels
• Hollow vessels

Finger imaged at 19 keV
Finger imaged at 26 keV
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Phantom Designs
Shelley Medical Imaging Technologies
www.simutech.com
SolidWorks Model
Preliminary Sketch
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Material Considerations

• Ideal Material
• ReoFlex 20 polyurethane resin
• Actual Material
• Z-Corps ZP 102 plaster-based powder
• Compatible with printing machine used for
  prototyping process
• Ideal for printing fine-detail or thin-walled
  models
• Radiotranslucent and flexible formulation
• Option to infiltrate with Synair Corporation
  Por-A-Mold polyurethane resin

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Schedule
Research
Material Testing Design
Manufacturing
Testing
FOR MORE INFO...
http//vubme.vuse.vanderbilt.edu/srdesign/2003/gro
up12/NCIIA20Grant20Proposal.htm
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Current Status

• Work Completed
• Design Finalized
• Manufacturer Contacted
• Prototype Being Made
• Expected by Early Next Week

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Future Plans

• April
• Create Pump for Dosimetry Testing
• Start Testing
• Test Dosimetry for Imaging
• Test for Optimal Stereo Angle
• Write Final Report
• Create Poster

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Testing

• Create Pump for Dosimetry Testing
• Run Tests
• Test Dosimetry for Imaging
• Acquire series of images with different dilutions
  of contrast agent
• Test for Optimal Stereo Angle
• Acquire series of images at different rotation
  angles

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Team and Resources

• Advisor Dr. Frank Carroll, M.D.
• Monochromatic x-ray machine
• W.M. Keck Free-electron Laser (FEL) Center at
  Vanderbilt University
• Materials and tools provided by BME Department
  and FEL Center
• Polyurethane resins from outside contractors

Photograph of device with laser cover
removed http//www.vanderbilt.edu/fel/Xray/manuscr
ipts/final20report20for20ONR20grant2020021218
.doc
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Questions?
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