Key Achievements

1
Computer Assisted Design of Transport Processes
in the Human Brain Laboratory for Product and
Process Design, Director A. A. LINNINGERCollege
of Engineering, University of Illinois,Chicago,
IL, 60607, U.S.A. Grant Support NSF, Medtronic,
Susman and Asher Foundation.

• Problem Statement
• Prediction of large deformations of the brain
  parenchyma based on Fluid-Structure Interaction
  modeling.
• Coupling of the brain parenchyma, vascular and
  ventricular system in the human brain.
• Targeted Drug delivery to specific substructures
  of the human brain.

Prediction of Drug Distribution

• Key Achievements
• Geometric reconstruction of patient-specific
  brain dimensions based on MRI data
• Patient-specific dynamic analysis of CSF flow in
  the human brain
• Prediction of drug distribution
• Future Goals
• Optimal Drug Delivery to the Human Brain.
• Feedback control systems to better treat
  Hydrocephalus.

Estimation of Penetration Depth

• Higher Treatment Volumes were realized for high
  flow Infusion at the thalamus
• The total treatment volume at the end of 4 weeks
  was found to be 0.107 cc

Prediction of treatment volume in a 2D coronal
cut of a human brain using NGF as drug