Histology for Pathology Male Genital Tract - PowerPoint PPT Presentation

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Histology for Pathology Male Genital Tract

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Histology for Pathology Male Genital Tract Theresa Kristopaitis, MD ... Testis On a cross section of testis identify seminiferous tubules and interstitial connective ... – PowerPoint PPT presentation

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Title: Histology for Pathology Male Genital Tract


1
Histology for PathologyMale Genital Tract
  • Theresa Kristopaitis, MD
  • Associate Professor
  • Director of Mechanisms of Human Disease
  • Kelli A. Hutchens, MD, FCAP
  • Assistant Professor
  • Assistant Director of Mechanisms of Human Disease
  • Loyola Stritch School of Medicine

2

Male Reproductive System Histology Objectives
  • Describe the pathway for sperm conduction through
    the genital ducts.
  • Testis
  • On a cross section of testis identify
    seminiferous tubules and interstitial connective
    tissue.
  • Name the two types of cells in the seminiferous
    tubules - spermatogenic (germ) and supporting
    (Sertoli cells).
  • Explain the function of Sertoli cells.
  • On an HE stained section, identify interstitial
    cells of Leydig and explain their function.
  • Prostate Gland
  • On a section of the prostate, identify prostate
    glands and stroma.
  • Identify corpora amylacea (prostatic secretions)
    and explain their significance.
  • On a high power view of the prostate describe the
    epithelium that lines the glands.
  • Penis
  • On a cross section of the penis identify the
    corpora cavernosa, corpora spongiosum, urethra
    and epidermis.

3
  • Spermatozoa leave the seminiferous tubules via
    the tubuli recti
  • From the tubuli recti to the rete testis and
    efferent ductules which lead to the
    extratesticular ducts
  • Ductus epididymis
  • Ductus / Vas deferens
  • Ejaculatory ducts of the prostate
  • Urethra

4
Seminiferous Tubules
  • Consist of germinal epithelium and basement
    membrane
  • Epithelium contains various stages of
    spermatogenic cells and supporting cells
    Sertoli Cells
  • Sertoli cells provide blood-testis barrier,
    secrete fructose, androgen binding protein,
    anti-Mullerian hormone, inhibin, and activin
  • Connective tissue in between tubules contains
    tubuli recti, vessels, and Leydig cells
  • Leydig / interstitial cells secrete testosterone

5
Seminiferous tubule
6
Germinal Epithelium
Sertoli Cell
Leydig cell
7
Prostate
Composed of branched tubuloalveolar
glands Lumens often contain prostatic secretions
corpora amylacea
8
Corpora amylacea
High power view of gland with its simple columnar
epithelium that is highly folded creating an
irregular lumen.
9
Penis
Full cross section image University of Michigan
Medical School Histology website
10
urethra
Corpora spongiosum
Corpora Cavernosa
11
Corpora Cavernosa of the Penis
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