Title: Incorporating a Pressure Sensor-Transmitter (RF) Complex on Transseptal Cannula for use with TandemHeart
1Incorporating a Pressure Sensor-Transmitter(RF)
Complex on Transseptal Cannula for use with
TandemHeart PTVA System Team Members Mihoko
Hashimoto Lauren Kokai Nitin
Narayana Katie OCallaghanProject Advisors
David H.J. Wang, Ph.D. Douglas E. Smith,
Ph.D. Dennis Kopilec Marlin H.
Mickle, Ph.D.December 5, 2003
University of Pittsburgh Senior Design BioE 1160
2Overview
- TandemHeartTM - A centrifugal pump that allows
for fast deployment of oxygenated blood from the
Left Atrium (LA) to the femoral artery and thus
bypassing the Left Ventricle (LV). - Advantages Reduced workload on LV, possible
healing of LV, helps maintain blood circulation
and organ perfusion during heart surgery, bridge
to transplant. - Audience Cardiologists and Cardiac Surgeons
(maintaining blood flow), patients suffering from
myocardial infarction or acute carditis, patients
with deteriorating LV functionality waiting for a
transplant, patients recuperating from heart
surgery (increase speed of LV healing).
3Overview
- Problem
- Unmonitored changes in LA pressure (below a
certain pressure threshold) may pose a threat to
the patient due to a potential suck down of
tissue (overdrainage of LA). Cause tissue damage
and reduce blood flow. - Solution
- Real time pressure readings in the LA can
possibly prevent the tissue suck down. - Incorporate a pressure sensor into the tip of the
Transseptal Cannula along with the use of
RF-technology for signal transmission. - Effectively determine an appropriate pump speed
depending on patients conditions without further
invasive processes.
4Project Goals
- The ultimate goal of this project is to enable
real-time measurements of Left Atrial Pressure
(LAP) with TandemHeart use, by placing a
barometric absolute pressure (BAP) sensor chip
(Kavlico sCAP1) at the tip of the cannula. - Incorporation of RF transmitter complex to
transmit the real-time measurements without need
for wiring. - Determine durability of the device after
coating using simulated conditions. - High Level Timing Goals
- Analysis of pressure sensor properties
manufacturing limitations - Development of sensor-signal transmitter (RF?)
complex - Establish that device meets PDS under simulated
clinical use conditions - Verify accurate signal transmission in intended
clinical environment
5Future Project Opportunities
- Successful completion of this project could be
used for future development of a safety pump
speed adjust feature in the pump controller. - By developing an algorithm to respond to low LAP
conditions, the controller on the TandemHeartTM
will be able to auto-adjust (a vital safety
feature) by decreasing pump speeds. - The sensor-RF transmitter complex could also be
applied for countless other internal biomedical
devices!!
6Features Benefits
- Pressure sensor
- ? provide potential for accurate real-time
monitoring of LAP to prevent suck down of LA - ? allow for more accurate/sensitive pump speed
for individual patients condition - (less need for highly trained system operator)
- RF transmitter
- ? no need for wiring
7Group Object Tree
8Design Sketch
Receiver
Pressure Sensor
1.2mm
RF Transmitter
1.5mm
9Design Alternatives
- Pressure sensor other manufacturers
- Various sensor placements
- Single sensor
- Inside lumen / exterior
- Various RF transmitter placements
- Further away from cannula tip
- Integrated on microchip
- Potential need for extra transmitter outside body
- Potential need to include amplification of signal
in order to transmit through the chest wall - Pressure signal output via wire (instead of RF
transmitter)
10Group Function-Means Tree
11Competitive Analysis
- Integrated pressure sensing capabilities dont
yet exist! - Existing Designs (circulatory support)
- Centrifugal flow pumps
- Thoratec, Arrow, MicroMedical, MedQuest, Kriton
Medical, Terumo - Other forms of circulatory assistance
- IABP (Intra-Aortic Balloon Pump)
12Competitive Analysis
- Strengths of our Design
- Incorporated LAP-sensor on cannula tip
- no need for separate LAP line
- safety feature to prevent LA suck down
- real-time monitoring of patient LAP
- RF pressure signal transmission
- no wires for signal output
- future integration of auto safety adjust in
controller
- Weaknesses of our Design
- More complicated (more potential failure modes)
- Higher production cost
13Technology
- Using new technology
- MEMS pressure sensor chip
- RF data transmission (of pressure signal)
- Engineering Models
- SolidWorks design modifications
- Simulated pressure/flow loop systems
14Team / Resources
- Advisors
- Drs. David Wang Doug Smith, Dennis Kopilec
- (CardiacAssist, Inc.)
- ? Medical device design, cannula design, clinical
knowledge - Dr. Marlin Mickle
- (Dept. of Electrical Engineering, Univ. of
Pittsburgh) - ? RF technology
- Locations
- Lab space for testing of design CardiacAssist,
Univ. of Pittsburgh - Swanson Center design and RF systems
15Team / Resources
- Equipment
- Pump system supplies and testing equipment
CardiacAssist, Inc. - Pressure sensor Kavlico, Inc.
- RF transmitter not yet identified
- Manufacturing to be determined by CardiacAssist,
Inc.
16Projected Task Schedule
17Personal Responsibilities
Project Criteria Milestone 1 (30) Milestone 2
(30) Milestone 3 (10) Milestone 4
(10) Milestone 5 (5) Milestone 6
(7.5) Milestone 7 (7.5)
18Current Status
- Tasks completed as of 12/5/2003
- Group meeting with CardiacAssist
- -Determined scope of project and documented
specific deliverables CAI requires from students
at conclusion of project - Determined Product Design Specifications
- -Communicated project schedule and goals through
Gantt chart, Function Means Tree, Object Tree - Group meeting with U of P advisor Marlin H.
Mickle, Ph.D - -Students presented summary of project goals and
relevant design information, discussed student
needs for assistance and obtained background info
on RF technology and circuit integration
components, as well as anticipated difficulties - Order placement for Kavlico sCAP 1 BAP sensor
chips (5)
19Acknowledgements
- CardiacAssist
- Drs. Doug Smith David Wang, Dennis Kopilec
- Project funding
- Provision of pump system supplies testing
equipment - Lab space
- Great project opportunity!!
- Dr. Mickle
- RF technology expertise project guidance re
electrical aspects - Lab space
- MG
- Project development guidance
- FDA background info (ad nauseum)
- Moral support!
20Questions.?