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Cannabis and Schizophrenia

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... of neural signals Correlation Between THC and Schizophrenia A relatively small proportion of cannabis users develop psychosis ... of dopamine in a ... – PowerPoint PPT presentation

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Title: Cannabis and Schizophrenia


1
Cannabis and Schizophrenia
2
Major Constituents of Cannabis
  • The two major substances found in cannabis
    include tetrahydrocannabinol (THC) and
    cannibidiol (CBD)
  • THC is the major psychoactive substance found in
    cannabis
  • THC acts as an agonist while CBD acts as an
    antagonist by having the same effect as
    neuroleptics

3
THC
  • THC effectively acts as a dopamine agonist, thus
    blocking the reuptake of dopamine and L-DOPA
    (which stimulates the synthesis of dopamine)
  • Produces an overactivity of dopaminergic synapses
    in the nucleus accumbens
  • Dopaminergic neurons are involved in
    reinforcement.

4
Areas of The Brain Most Affected by THC
  • Basal Ganglia, and the Cerebellum (Motor Tasks)
  • Hippocampus (Short-Term Memory)
  • Cannabinoids inhibit the transmission of neural
    signals

5
Correlation Between THC and Schizophrenia
  • A relatively small proportion of cannabis users
    develop psychosis
  • Explained by the amount and duration of the
    consumption of cannabis, its strength, and also
    the age at which individuals are exposed to
    cannabis
  • Genetic factors COMT (catechol-O-methyl
    transferase)

6
Those Most at Risk of Developing Schizophrenia
  • Users under the age of 21, as the human brain has
    not fully matured
  • Users under the age of 15 are 4.5 times more
    likely to develop psychosis by the age of 26
  • An increase in the concentration of dopamine in a
    developing brain increases the likelihood of
    developing schizophrenia in early adulthood

7
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8
Physical Harm vs. Dependency
9
CBD
  • Cannabidiol (CBD) represents up to 40 of
    cannabis extracts
  • Found to reduce schizophrenic symptoms by
    blocking dopamine receptors
  • Prevents the storage of monoamines in synaptic
    vesicles
  • Cannabidiol has no affinity for CB1 receptors
  • http//www.youtube.com/watch?vgAfs_No8lE8
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