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Tablet Coating

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Diclofenac Sodium. Doxylamine Succinate. Garlic Tablets, Omeprazol, Pentaprazole, Pentoxyfyline, Rabeprazol , Serrosipeptadise Aqueous coating system & Organic ... – PowerPoint PPT presentation

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Title: Tablet Coating


1
Tablet Coating
  • Why coat tablets?
  • Types of coatings
  • sugar coating
  • film coating
  • press coating (compression coating)

2
Sugar Coating
  • stages involved
  • sealing of tablet core
  • subcoating
  • smoothing
  • colouring
  • polishing
  • printing

3
Film Coating
  • involves spraying a solution of polymer
    pigments plasticizers onto a rotated, mixed
    tablet bed
  • forms a thin, uniform film on tablet surface
  • materials
  • polymers
  • solvents
  • plasticizers
  • colorants

4
Film Formation
latex particles dispersed in aqueous phase
formation of thin film with water evaporation
through film
continuous film
5
Coating Process
  • coating pans

6
Coating Process
  • fluid beds

7
Important Processing Parameters
  • inlet and bed temperatures
  • relative humidity
  • atomization air pressure
  • liquid spray rate
  • droplet size
  • drying time

8
Coating Problems
  • picking/chipping
  • roughness
  • sticking
  • film cracking/peeling

9
Normal Coating
10
Enteric-coated
  • coating resists dissolution or disruption in
    stomach but not in intestines
  • used for drugs that are unstable, irritating to
    stomach

11
Enteric Coating
12
Press Coating
  • use of compression to form coat around a
    pre-formed core
  • used mainly to separate chemically incompatible
    materials
  • also dual release patterns possible
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