Efficacy of a PEG/PG based Ocular Lubricant to Reduce Transient Visual Degradation

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Efficacy of a PEG/PG based Ocular Lubricant to
Reduce Transient Visual Degradation

• Rolando Toyos, M.D.
• Whitney Hauser, O.D.

The author of this poster has received research
funding from Alcon Laboratories.
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Rolando Toyos, M.D.

• Medical Director and Founder
• of Toyos Clinic,
• Memphis, Tennessee.
• President of The Sports
• Ophthalmology Society of
• America
• Team Ophthalmologist for the
• Memphis Grizzlies

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Whitney Hauser, O.D.

• Clinical Director, Toyos Clinic,
• Memphis, Tennessee.
• Adjunct Faculty member,
• Southern College of Optometry.
• Center Director, TLC Laser Eye
• Centers, Memphis, Tennessee.

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The Effect of the PEG/PG based Ocular Lubricant
on Forced Stare

• The forced stare mimics activities such as
• Driving a car
• Flying a plane
• Playing certain sports (i.e. baseball)
• The forced stare is used to measure visual
  degradation, a factor related to dynamic visual
  acuity.

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The Effect of the PEG/PG based Ocular Lubricant
on Forced Stare

• Prospective, open-label, single-arm, single
  center study
• 30 subjects enrolled
• Eligibility requirements
• Bilateral BCVA 20/20
• History of episodic Dry Eye
• Minimum TBUT 10 seconds at baseline

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The Effect of the PEG/PG based Ocular Lubricant
on Forced Stare

• Subjects stared at Landolt E (adjusted to 20/20)
  at a distance of 60 feet and 6 inches without
  blinking and reported when target was unclear
• Visual degradation measured
• Before drop instillation of PEG/PG based
  lubricant
• 5 minutes after instillation of PEG/PG based
  lubricant
• Endpoint Change in subject-reported clear
  vision

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The Effect of the PEG/PG based Ocular Lubricant
on Forced Stare

• Mean Clear Vision (MCV) duration 6.46 seconds
  ( 3.00 seconds) before instillation
• MCV duration 8.32 seconds (3.86 seconds) after
  bilateral instillation of lubricant

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The Effect of the PEG/PG based Ocular Lubricant
on Forced Stare

• Instillation of the PEG/PG based Ocular Lubricant
  significantly increased MCV duration
• Improvement was observed in 26 of 30 subjects
  (87)
• Mean Increase 2.22 seconds
• Maximal MCV 7.6 seconds

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The Effect of the PEG/PG based Ocular Lubricant
on Forced Stare

• 4 subjects observed a decreased duration of MCV
  post-treatment
• Mean Decrease 0.54 seconds
• No adverse events were reported for this study

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Conclusion

• Bilateral acute administration of PEG/PG ocular
  lubricant reduced visual degradation in these
  patients, suggesting an improvement in tear film
  stablilization.
• These results warrant further study of PEG/PG
  ocular lubricant use to improve dynamic visual
  acuity which is important in sports such as
  baseball and other activities like flying and
  driving.