Diapositiva 1

1
N.O.E. lesson 3 module 2 The Nuclear
Overhauser Effect Prof. Claudio Santi
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
2
N.O.E. Introduction
?
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
3
N.O.E. Introduction steady-state
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
4
N.O.E. Introduction steady-state
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
5
N.O.E. Introduction steady-state
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
6
N.O.E. Introduction stady-state
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
7
N.O.E. Introduction stady-state
Influence of magnetic field
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
8
N.O.E. Introduction stady-state
Influence of external relaxation sources
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
9
N.O.E. Introduction stady-state
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
10
N.O.E. Introduction stady-state
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
11
N.O.E. Introduction stady-state
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
12
N.O.E. Introduction stady-state
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
13
N.O.E. Introduction NOE-diff
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
14
N.O.E. Example NOE-diff
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
15
N.O.E. Example stady-state
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
16
N.O.E. Example stady-state
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
17
N.O.E. Example stady-state Geometry of
trisobstituted olefines
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
18
N.O.E. Example stady-state Geometry of
heterocycles
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
19
N.O.E. Example stady-state When the coupling
costants are not determinant
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
20
N.O.E. Example stady-state Sometimes it is
not usefull
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
21
N.O.E. Example stady-state Attribution of
the faces in cyclic compounds
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
22
N.O.E. Example stady-state Attribution of
the faces in cyclic compounds
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
23
N.O.E. Example stady-state Assignment of
similar groups
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
24
N.O.E. Example stady-state Conformational
analysis
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
25
N.O.E. Transient NOE
I
I
s
I
I
I
I
s
s
s
s
NOE
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
26
N.O.E. Transient NOE and Distances
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
27
N.O.E. NOESY
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
28
N.O.E. NOESY
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
29
N.O.E. ROESY
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
30
N.O.E. ROESY
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
31
N.O.E. ROESY
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
32
Additional slidesnot for the presentation
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ADDITIONAL
N.O.E.
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
34
ADDITIONAL
N.O.E.
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
35
ADDITIONAL
N.O.E.
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
36
ADDITIONAL
N.O.E.
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
37
ADDITIONAL
N.O.E.
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia
38
ADDITIONAL
N.O.E.
Prof. Claudio Santi Dipartment of Chemistry and
Technology of Drugs University of Perugia