Our students do well!

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Summary
Summary
Our students do well! Our programs are strong,
particularly Postgraduate Residency and Clinical
Fellowship We need to improve our Undergraduate
Education performance
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Resident Presentation Nir Lipsman, R4
Neurosurgery 2nd year PhD student through
IMS Supervisor Dr Andres Lozano Surgeon
Scientist Program Clinician Investigator
Program CIHR Fellowship
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Probing and modulating neural circuitry
underlying reward and emotional processing
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• Probing and modulating neural circuitry
  underlying reward and emotional processing

• Intraoperative single-unit recording (SUR)
• Post-operative multi-unit recording (MUR)
• Perioperative frequency analysis, interregional
  coherence and MUR

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Probing and modulating neural circuitry
underlying reward and emotional processing

• Deep Brain Stimulation

• Intraoperative single-unit recording (SUR)
• Post-operative multi-unit recording (MUR)
• Perioperative frequency analysis, interregional
  coherence and MUR

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PhD Supervisor Dr. Andres M. Lozano
Collaborators University of Toronto Dr.
Jonathan Dostrovsky (Physiology) Dr. Bill
Hutchison (Physiology) Dr. Peter Giacobbe
(Psychiatry) Dr. Sidney Kennedy
(Psychiatry) Dr. Blake Woodside
(Psychiatry) Dr. Jeff Daskalakis
(Psychiatry) Dr. Roger McIntyre
(Psychiatry) Dr. Adam Anderson
(Psychology) USC/McGill Dr. Antoine Bechara
(Neurology/Psychology) University of Hong
Kong Dr. Savio Wong (Psychology) University
of Ottawa Dr. Georg Northoff
(Psychiatry/Psychology) Dr. Takashi Nakao
(Psychology)
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• Probing and modulating neural circuitry
  underlying reward and emotional processing
• Acquire unique data to answer questions not
  previously subject to empirical testing (e.g. The
  nature of self and its relationship to reward)
• Develop novel therapeutic options for patients
  with no treatment alternatives (e.g. Treatment
  resistant psychiatric disease)

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Single-neuron activity during Self Task in
Subgenual Cingulate Gyrus during Depression DBS
Own
Famous
Neutral
Mean firing rate for Own is significantly higher
in first second of stimulus presentation vs.
Famous vs. Neutral (plt0.05)
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Single-neuron activity during Self Task in
Subgenual Cingulate Gyrus during Depression DBS
Own
Famous
Neutral
Mean firing rate for Own is significantly higher
in first second of stimulus presentation vs.
Famous vs. Neutral (plt0.05)
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Frequency of Self
Logarithmic representation of local field
potential frequencies
FAMOUS
NEUTRAL
OWN
Diminished power in alpha band
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Implications

• Tasks now under development will look at
  decision-making under uncertainty, emotion
  recognition and reward anticipation
• From Neurophysiology to Clinical Research
• Depression
• Bipolar Disorder
• Obsessive-Compulsive Disorder
• Anorexia Nervosa
• Schizophrenia
• Drug Addiction
• Alcoholism

Disorders of self processing and primary reward
dysfunction
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Depression
Alzheimers Disease
DBS can modulate neural circuits underlying mood
and memory
Mayberg et al 2005 Laxton et al 2010
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Modulating Neural Circuitry
Disorder Target Subjects Status
Obsessive-Compulsive Disorder Inferior Thalamic Peduncle 6 Operated on 1 Now recruiting
Bipolar Disorder type II Subgenual cingulate gyrus (SCG) 6 REB Approved Now recruiting
Anorexia nervosa, restricting subtype SCG and Nucleus Accumbens (NAcc) 12 REB Approved Now recruiting
Schizophrenia NAcc and Ventral Tegmental Area (VTA) 6 REB Approved Now recruiting
Canadian First Global First
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(No Transcript)
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Coming your way in 2011-12!
Coming your way in 2011-12!
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Also Coming Your Way!
Also Coming Your Way!
Strategic Planning Initiative 2011-12
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Also Coming Your Way!
Also Coming Your Way!
Strategic Planning Initiative 2011-12

• Co-Chairs Late fall, early winter
• Tagline TBD
• Retreat January 2012
• Survey Monkey Sept 2011
• Stra James Rutka and Bryce Taylor
• Facilitator Helena Axler
• Timeline tegic Foci Education, Research,
  Faculty Development, Best Practices, Integration

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Keep your eyes open for.....
Keep your eyes open for.....
A New Department of Surgery Brand!
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Thank you!
Thank you!