Cumulative Initiation of Effective Antimicrobial Therapy and Survival in Septic Shock

1
Cumulative Initiation of Effective Antimicrobial
Therapy and Survival in Septic Shock
survival fraction
1.0
cumulative antibiotic
initiation
0.8
0.6
fraction of total patients
0.4
0.2
0.0
12-24
24-36
0-0.5
0.5-1
9-12
36
1-2
2-3
3-4
4-5
5-6
6-9
time from hypotension onset (hrs)
Kumar et al. CCM. 2006341589-96.
2
Funk and Kumar, Critical Care Clinics 2011 (in
press)
3
Mortality Risk with Increasing Delays in
Initiation of Effective Antimicrobial Therapy
Kumar et al, CCM. 2006341589-96.
4
Risk of Death with Increasing Antimicrobial
Delays Subgroups
N
all
2154
documented
1695
459
suspected
culture
1546
608
culture -
769
bacteremia
bacteremia -
1385
community
1242
nosocomial
912
584
gram
gram -
768
fungal
131
Survival 0.79/1.119xx delay (hrs)
838
respiratory
urinary tract
230
intra-abdominal
641
skin/soft tissue
156
1.0
1.1
1.2
1.3
Kumar et al, CCM. 2006341589-96.
Adjusted Odds Ratio of Death