CTVP?CTOP???????????280???????

1
CTVP?CTOP???????????280???????

• ???????????????
• ??????????
• ?? ???

2
? ?

• ???????(nonHodgkins lymphoma,NHL)??????????,????
  ??????
• CHOP??????????NHL?????????1
• ?????(THP)??????????,???????ADM??,?????????????ADM
  ?2
• ????(VDS)???????????(VCR)??,?????????VCR3

Mckeley EM,Gottlieb JA,Wilson
HE,eta1.Hydroxydaunomycin (Adriamycin)
combination chemotherapy in malignant lymphoma
J.Cancer,1976,3814841493.
Gallaminl A,Stelitano C,Calvi R,et a1.Peripheral
T-cell lymphoma Unspecified(PTCLU)a
new prognostic model from a
retrospective multicentric clinical
studyJ.Blood,2004,103(7)
24742479.
3
?????

• ???2000?1??2005?12????280????????(NHL)??,????CTVP?
  ???162?,CTOP????118?,??????????????????????
• 280???????????????1?2

4
?1 280???????????????
?LDH????? HGB ???? IPI??????
5
?2 280???????????????
?DLBCL???B??????ALCLB???B??????Burkitts???
???FL??????MALT????????MCL??????PTCLU??T?
??????????NK/TCLNK/T??????ALCLT???T??????AIT
CL???????????
6
????

• 162???CTVP????
• CTX 750mg/m2 d1,THP 40mg/m2 d1,VDS 3mg/m2
  d1,PDN 60mg/m2 d1-d5,q21d,?4-8???(??5??)
• 118???CTOP????
• CTX 750mg/m2 d1,THP 40mg/m2 d1,VCR 1.4mg/m2
  d1,PDN 60mg/m2 d1-d5,q21d,?4-8???(??5??)
• CTVP?97???????????(59.8),??????40Gy
• CTOP?62???????????(52.5),??????40Gy

7
??????

• ?????(OS)
• ???????????????????????????
• ???2009?12?,280???5???
• CTVP???????32??(271??)
• CTOP???????30??(1-71??)

8
??????

• ?WHO????????????
• ????(complete response, CR)
• ????(partial response, PR)
• ??(stable disease, SD)
• ????(progressive disease, PD)
• CR?CR/ ???????100
• OR? (CRPR) / ???????100
• ????? (CRPRSD) / ???????100
• ??????

9
?????

• ??SPSS 16.0?????????
• Kaplan-Meier?????????????
• ????????Log rank??
• ??Cox???????????

10
?3 ??????????
? ? ?? ? ? ? ? ? ? ? ? ??? () P? ????? () P?
? ? ?? CR PR SD PD ??? () P? ????? () P?
CTVP? CTOP? 160 112 68 44 49 37 30 20 13 11 73.13 72.32 gt0.05 91.88 90.18 gt0.05
?CTVP?2????????? CTOP?6?????????
11
CTVP??CTOP?????
CTVP CTOP ??OS 62??
41?? 1?OS 91.0 90.0 3?OS 81.2
55.1 5?OS 43.2 22.3 Plt0.05
12
?4 280??????????
13
? ?

• ?????(THP)?????????,?????????,???????????,???
  ADM?????,?????????????ADM
• ????(VDS)?????????????,??????????,???????????VCR?3
  ?,??VCR?????,???????

Barnett CJ,et aI.J Med Chem,197821(1)88
14
? ?

• Saij?4??,THP-COP???????????32?????NHL??,THP-COP?
  ??3-6?(??3?),????18-46.5Gy(??40.0Gy),????19??(1-
  47??),3?OS81.3,3?PFS74.9
• Saij Ohga,
  Katsumasa Nakamura, Yoshiyuki Shioyama , et al.
  
• Stage I and
  II Non- Hodgkins Lymphoma Results of Combined
  
• of THP-COP
  Chemotherapy and Radiotherapy. Radiation
  
• Medicine
  Vol.23 No.3, 156161 p.p.,2005.

15
? ?

• Ueda T?6????,??VDS????7????????,3?HD,4?NHL,??CR?
  PR,??????4-24??
• ???VDS?????????16????????,11??CR?PR,??4?VCR????,??
  ?VDS?????2??PR
• 
  
• 
  Ueda T,Masaoka T,Shibata H,et al. Administration
  of
• 
  vindesine sulfate for the treatment of
  malignant
• 
  hematological tumors. Gan To Kagaku Ryoho,1982
• 
  Feb9(2)306-15.

16
? ?

• ??2000?1?-2005?12????NHL??280?,??CTVP????162?,CTOP
  ????118?
• CTVP?OR?73.13,?????91.88
• CTOP?OR?72.32,?????90.18(pgt0.05)
• CTVP?5?OS43.2,?????62??
• CTOP?5?OS22.3,?????41??(plt0.05)
• ????,CHOP??(?ADM)??????NHL?CR?45-55,5?OS30-35

Fisher RI.Cyclophosphamide,doxorubicin.vineristine
, and prednisone versus intensive chemotherapy in
non-HodgkinS lymphom. Cancer Chemother
Pharmaco1.1997.40( Supp1)S42-46
17
? ?

• Ueda T?????,VDS???????????????,??,?????????,?VDS??
  ?????????VCR
• ?????,?????????????????????????????????
• ?????,CTVP????????????14.81,???????????????1.85,
  ????CTOP??31.36?5.93(plt0.05)

Ueda T,Masaoka T,Shibata H,et al. Administration
of vindesine sulfate for the treatment of
malignant hematological tumors. Gan To Kagaku
Ryoho,1982 Feb9(2)306-15.

18
? ?

• ?VDS?CTVP????????????????????CTOP????,?????????CTO
  P??,????????????

19
????