Viruses

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Viruses
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Virus Structure

• Nucleic acid encased in a protein coat (capsid)

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Viral Replication

• Only reproduce when they enter a host cell
• They lack ribosomes and enzymes necessary for
  protein synthesis and simple metabolism

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Viral Genome Structure

• dsDNA
• ssDNA
• dsRNA (reo)
• ssRNA
• Serve as mRNA ()
• Serve as template for mRNa (-)
• Serve as template for DNA (retro)

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Bacteriophages

• Virsus that attack bacteria
• Two types of reproductive cycles
• Lytic
• Lysogenic

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Lytic and Lysogenic Cycles
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HIV is a Complex Animal Virus

• CD4 receptors
• Endocytosis
• Reverse Transcriptase
• DNA Incorporation
• Produces genome for new virus
• Assemble HIV particles
• Exit by budding or lysis

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Treatment

• AZT Blocks replication
• Protease inhibitors blocks building of capsid

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Treatment

• Chemokines
• Blocking Receptors
• Defective HIV genes

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