Iodine Isotopes

1
Iodine Isotopes

• Chemistry Radioactivity of Iodine
  Moataz Mohamed

• Radioisotope Therapy (RIT-I131)
  Rowan Mohamed
• Mohamed Shady

2
??????? ??????? ??!!
3
??????? ????? ??!!
4
(No Transcript)
5
(No Transcript)
6
I- Chemistry of Iodine
7
Discovery of Iodine

• Discovery of
• Iodine element
• by
• Bernard Courtois in 1811

8
Physical Properties

• violet-dark gray solid
• Density 5 g/cm3

• Melting Point 114C
• Boiling Point 185C

9
Atomic Properties

• Atomic Weight 127
• Electrons/shell 2,8,18,18,7

• 53 Proton
• 74 Neutron

10
Occurrence on Earth
11
II- Radioactivity of Iodine
12
Iodine isotopes

• Isotopes are atoms of the same
• element having the same
• number of protons but different
• number of neutrons.
• There are 37 isotopes of Iodine
• Ex I127, I129, I131
• The only stable isotope of Iodine is I127.

13
Radiation Half-life Period

• If radiation is a form of energy .. Then it can
  not be created (First Low of Thermodynamics).
• So where does it come from???????????!
• The source of radiation is the loss in mass
  (EMC2)
• Half-life period is the time after which the mass
  will reach half of its initial value.
• Half-life period is very important in determining
  the time needed for the radioactive substance to
  completely decay.

14
(No Transcript)
15
III- Radioisotope Therapy (RIT-I131)
16
Radiotherapy Iodine-131

• Definition.
• Medical use of IONIZING RADIATION in treatment of
  Cancer and Malignant cells .
• Radiotherapy Vs. Radiology ! !
• History of Radiotherapy
• Wilhelm Conrad Röntgen
• Marie Curie

17
Radiotherapy Iodine-131

• Mechanism of action
• DAMAGE OF DNA..
• Both strands ?
• Damage is inherited
• in cancerous cells .
• Free radicals
• ( hydroxyl radicals ) .

18
Radiotherapy Iodine-131

• Radioisotope Therapy ( RIT )

• INFUSION
• MIBG Neuroblastoma
• ORAL IODINE 131 Thyrotoxicosis
• RADIOACTIVE GLASS Hepatic cancer

INGESTION
19
Radiotherapy Iodine-131

• FELINE HYPERTHYRODISM

• Procedure ..
• Advantages ..
• Disadvantages ..

20
Radiotherapy Iodine-131

• Radiation protection.
• Based on

Time
Distance
Shielding
21
Radiotherapy Iodine-131

• 1- Reducing the time of an exposure reduces the
  effective dose proportionally.
• 2- Increasing distance reduces dose due to the
  inverse square law .
• 3- Adding shielding can also reduce radiation
  doses .

22
Thank You

• References
• http//en.wikipedia.org/wiki/Isotopes_of_iodine
• Merck Index of Chemicals and Drugs, 9th ed.
• General Chemistry (volume 2) by N.L. Glinka, Mir
  Publishing 1981
• General Chemistry by Linus Pauling, 1947 ed.
• Chemical Supplier Convicted of Diversion of
  Iodine

Moataz Mohamed
Rowan Mohamed
Muhamed Shady