Ebola

1
Homework 3 is due 4/11. Bonus 2 is due W
4/4. Bonus 3 is due F 4/27.
E. coli
Phage virus
Fungus from soil
Ebola
2
The Immune System

• Specific
• B-cells -gt antibodies
• T-cells

• Non-specific
• barriers

CB 43.2
3
Non-Specific Immune System Barriers
Skin- Dry Inhospitable Competition Secret
ions (lysozyme) Hairs and Mucus (protect
openings) Traps particles, swallowed Stomach
acid kills pathogens
CB 43.2
4
Skin protects us from most pathogens
CB 43.2
5
Non-Specific Immune System Barriers
Skin- Dry Inhospitable Competition Secret
ions (lysozyme) Hairs and Mucus (protect
openings) Traps particles, swallowed Stomach
acid kills pathogens
CB 43.2
6
esophagus
stomach
7
Non-Specific Immune System Barriers
Skin- Dry Inhospitable Competition Secret
ions (lysozyme) Hairs and Mucus (protect
openings) Traps particles, swallowed Stomach
acid kills pathogens
CB 43.2
8
The Immune System

• Specific
• B-cells -gt antibodies
• T-cells

• Non-specific
• barriers

CB 43.2
9
The Specific Immune System
10
B-cells and T-cells move through the circulatory
system scanning for pathogens
11
B-cells develop in bone marrow T-cells in the
thymus
CB 43.10
12
B-cells make and secrete antibodies
CB 43.12
13
Variable region
An Antibody
Constant region
CB 43.8
14
Antibodies recognize and bind to antigens
CB 43.7
15
B-cells male antibodies that bind to antigens
marking them for destruction
Marked for destruction by WBC
CB 43.12 and 19
16

• What about damaged or abnormal cells?
• Viral infections
• Cancer cells
• Non-functional cells

17
T-cells recognize and destroy abnormal cells
CB 43.16
18
Immune System Overview
CB 43.14
19
It can take 7-14 days to produce sufficient
antibodies to eliminate a pathogen
CB 43.13
20
Memory B-cells make the response to a second
exposure more rapid
This is how vaccines work.
Marked for destruction by WBC
CB 43.17
21
Vaccines work via memory B-cells that make the
response to a second exposure more rapid
CB 43.13
22
The immune system during HIV infection
23
Homework 3 is due 4/11. Bonus 2 is due W
4/4. Bonus 3 is due F 4/27.
E. coli
Phage virus
Fungus from soil
Ebola