Modelling from Sequence to Gene Regulatory Network to Phenotype

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Modelling from Sequence to Gene Regulatory
Network to Phenotype
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Network Expression
The gene regulation network expresses as gene
activation over time
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3
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Gene activation
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Time
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State Spaces
If the system state at a given time step is
determined by the previous system state, the
dynamics can settle into basins of attraction,
in which the system is robust to perturbation.
But some changes can push the system to different
behaviour.
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System State After Single Perturbations
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System State After Single Perturbations
Perturbation
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System State After Single Perturbations
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System State After Single Perturbations
Perturbation
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System State After Single Perturbations
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System State After Single Perturbations
Perturbation
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System State After Single Perturbations
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System State After Single Perturbations
Perturbation
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System State After Single Perturbations
The dynamics of the system have changed
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System State After Single Perturbations
Perturbation
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System State After Single Perturbations
The system has changed again
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Such complex systems dynamics are being studied
in models of gene regulation
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System State After Single Perturbations