Romanovs and Revolution

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Romanovs and Revolution

• A Genetic History Mystery

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The Romanovs
Tsar Nicholas II
Alexandra
Olga
Tatiana
Alexei
Marie
Anastasia
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Grigory Rasputin
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Hemophilia

• Caused by a single, recessive allele.
• This allele codes for a blood-clotting protein.
  If the protein is defective, then the blood does
  not clot properly.
• Untreated, victims often die in childhood or teen
  years, rarely live to adulthood.

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The Windsor Pedigree
This pedigree shows who had hemophilia in the
Windsor family line. Why only males? And who are
the carriers?