Shear stress responsiveness in an embryonal chicken heart

1
Shear stress responsiveness in an embryonal
chicken heart
M. Pourquie1, P. Vennemann1, B. Groenendijk2, B.
Hierck2, S. Stekelenburg-de Vos3, N. Ursem3, R.
Poelmann2, F. Nieuwstadt1 ,J. Westerweel1 1Laborat
ory for Aero Hydrodynamics, Delft University of
Technology,The Netherlands 2 LUMC, Leiden, The
Netherlands 3Erasmus University, Rotterdam, The
Netherlands
1. motivation
1. motivation
2. Chosen test case a chicken embryos heart

• Early detection of growth errors during heart
  development
• Demonstrate and quantify relation between wall
  shear stress and growth errors, experimentally
  and numerically

Chicken embryo and artery system V Ventricle MC
Micro Clip length heart 1mm D heart 0.3mm
2. Gene expression of shear responsive genes
3. Gene expression of shear responsive genes
4. Micro PIV measurements
Expression of shear stress responsive factor on
reconstruction of heart showing places with high
shear (blue)
First measure-ments in a Vitelline vein, big
arrows Averaged flow profile
Heart
5. Numerics Curved boundary on Cartesian grid
6. Numerics Surface Representation
Heart

• Curved boundary represented by adding
  additional source terms to momentum equations,
  such that interpolated velocities on curve have
  correct value

Triangularization of boundary of heart interior
(only right cushions contracted)