Department of Microbiology, Harbin Medical University

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Medical Microbiology ? ? ? ? ? ?
Department of Microbiology, HMU ??????????????
Department of Microbiology, Harbin Medical
University
Department of Microbiology, Harbin Medical
University
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??? ??????

• ?5? ???????
• Mycology
• ??????? ???

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????

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• ???????(?????????)
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Classification
Based on molecular evidence base sequences from
ribosomal RNA (Patterson Sogin 1992)
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Taxonomy

• Kingdom EUMYCOTA  
• Phylum Dikaryomycota
•     Subphylum Basidiomycotina
•       Class Holobasidiomycetes
•         Order Agaricales
•           Family Agaricaceae
•             Genus Agaricus
•               Species Agaricus brunnescens
• - the edible
  mushroom.

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??(fungus)

• ????????
• ????

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???

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Medically important fungi

• Includes 4 phyla
• Ascomycota(????)
• Basidiomycota(????)
• Zygomycota(????)
• Mitosporic Fungi(Fungi Imperfecti,????)

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???(Zygomycotina)
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?????(Ascomycotina)
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???(Basidiomycotina)
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???(Deutemycotina)
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?????(Morphology)
??????????????

• ?????
• ?????(Yeast)
• ??????(Candida albicans)

• ??????
• ??(Mold)
• ????????

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?????

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• ???,?????

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?????

• ??(hypha)
• ??(Spore)

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??(Hypha)

• ???????,????,?????????????
• ?????????

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??(Spore)

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• ????
• ????

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??????

• ????(conidium)
• ?????????????????
• ????(thallospore)
• ?????????
• ?????(sporangiospore)

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?????????

• A.?????(????) B.????????(?????)
• C.????(?????) D.????(????)
• E.?????(??) F.?????(??)

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??????

• ????(??????)
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?????(Dimorphism)
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?????

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????????

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???????

• ??,???????8090
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??????

• ??????????????(chitin)??????
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• ??????

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??????

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??

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• ?????????,??????,???????????
• ?????????????????
• ??????????,??????????

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???????

• ?????(Sabouraud medium)
• ????
• ???????????????????
• ??????pH 46
• ??????22?28?
• ????????37??????
• ?????????

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????

• ??????
• ??????(Sabourauds glucose agar)
• 4 malt extract agar
• ??
• ????22 28oC,????????????37oC,pH4.0 6.0
• ?????????,14?

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????

• ?????(yeast colony)
• ??????(yeast-like colony)
• ?????(filamentous colony)

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???????

• ????(asexual reproduction)
• ????(sexual reproduction)

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???????

• ?????????????????????
• ???,?????60? 1??????
• 2?????10???0.1???2.5????
• ?????
• ?????????B?????B????????
• ???????

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??

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