Biomarkers and Drug Discovery

1
Biomarkers and Drug Discovery

• Angie Pannier
• Mathias Schubert
• Pat Dussault
• Surinder Batra

2
Charge

• Your task is to develop core ideas/projects for
  an 8-10M (1.25-1.5M per year for 5 years) NIH
  Center proposal.
• Specifically, you should consider the following
  questions

3
Briefly describe the core projects your group
would design for the Center. Please dream big.

• Cancer diagnostics
• Noninvasive
• Imaging-based (small molecules)
• Blood-borne (cellular or molecular targets)
• Detection with nanoparticles and then novel
  characterization techniques (to determine
  presence of ligand)
• Nanohybrid materials--Biomolecule
  capturing/filtering/microfluidics/readout
  techniques
• Detection for proteins, miRNAs, small molecules
• Diagnostics/Disease Screening Center (broader
  than cancer) Nanohybrid Biomaterials for
  Diagnostics
• Screen for miRNAs
• Sensitive RNA detection methods and probes
• Sequencing
• Profiles
• Bioinformatics
• Personalized Medicine
• Combine above with additional therapies

4
Identify the key faculty from both campuses to
involve in these projects. Include their
strengths. (UNMC on next slide)

• UNL Faculty Strengths
• Pat Dussualt
• David Hage
• Mathias Schubert
• Angie Pannier
• Eva Bachman-Schubert
• Ravi Saraf
• Yongfeng Lu
• Rebecca Lai
• Hendrik Viljoen
• Yuris Dzenis
• Ming Han
• Srivatsan Kidambi
• Dennis Alexander
• Greg Bashford
• Shadi Othman
• Jung Yul Lim

5
Identify the key faculty from both campuses to
involve in these projects. Include their
strengths.

• UNMC Faculty Strengths
• Surinder Batra
• Tony Hollingsworth
• Aaron Sasson
• Michelle Ouetllet
• John Davis
• Steve Remenga
• Subodh Lele
• Hamid Band
• Vimla Band
• Kay Wagner
• Ken Cowan
• CDDN (Sasha Kabanov and Tatiana Bronich)
• Sanjay Singh
• Howard Gendelman
• Ken Bayles

6
Identify external academic partners expertise
or equipment resources/strengths that are needed
to accomplish these projects.

• Better communication between campuses (and PIs)
• Expand nanofabrication facilities
  (microelectronics, prototyping)
• Microfluidics faculty member
• New graduate program

7
List potential industry/foundation partners
(think broadly) and what they would contribute.
Include reasons why they would be interested.

• J.A. Woollam Co.
• LICOR
• P G
• Abbott
• PanCan
• American Cancer Society
• All disease specific.

8
Describe how you would link the Center to other
campus resources.

• Links to CDDN, NCMN, MR-SEC, Center for
  Biotechnology, Nebraska Gateway for
  Nutrigenomics, UNMC Bioinformatics, Center for
  Neurosciences, Genetics Center

9
Increase communication between campuses
(intracampus)

• Stanford BioDesign analogy
• Poster Sessions
• Research talks
• Biologists/clinicians What are the problems?
• Engineers What are the tools?