?? (Myoinositol) ? Phosphatidylinositol ? Diacylglycerol ? Inositolpolyphosphate

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• ?? (Myoinositol) ?Phosphatidylinositol ?
  Diacylglycerol ?
  Inositolpolyphosphate

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• ??????????,?????,????????????(?????Charcot joint)

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Charcot Foot(????)

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Charcot Foot(????)
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Charcot Foot(????)
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• ????????? (A/B)
• 0.9-1.2 ??
• lt0.9 ????
• lt0.5 ?????
• gt1.2 ???? ??

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Fontaines Clinical Classification of Peripheral
Arterial Occlusive Diseases
Fontaines Classification
ABI Value
Cold sensation, numbness Intermittent
Claudication Pain at rest Ulcer,
necrosis (spontaneous gangrene)
0.9 0.7
Grade I Grade II Grade III Grade IV
0.7 0.4
0.4 0
0.2 0
??/???????????????????????(????), p39, ????,
2000(????)
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Prevalence Rate with PAD - NIDDM patients with at
least 1 risk factors -
ABI Taiwan ( Population 690 ) Asia ( Population 6768 )
gt 0.9 81.9 83.2
? 0.9 0.7 13.0 ---
? 0.7 0.4 4.3 ---
? 0.4 0.2 0.1 ---
PAD lt 0.9 17.5 16.8
2004 Hong Kong PAD SEARCH Meeting
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??????Rydel-Seiffer?????
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??????5.07,10??Semmes-Weinstein??????

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• 1????
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• 3??????
• ????358???????,??32???42???,??2?3??(Rith-Najarian
  et al. D iabetes Care 1992 15 1386-9)

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???

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• GLUT4?

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??????

• ????????????,?????????(collagen)
• ?????????????,?????
• ???????,???????? (Yue et al. Diabetes 198736
  296-299)

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Streptozotocin ???????????? (Yue et al. Diabetes
1987 36 296-299)

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• ???11?,2059 g,?? 945mg/dl,GHb
  9.53.6,????34.05.0N
• ????9?,163 10 g,??54477,GHb 19.62.8,????
  13.74.3N

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???????20??????? (Gottrup and Andersen, J Surg
Res 1981 31 61-68)
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???????Wagner????
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• ?????,?? total contact cast?????????
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1. ??,???????

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• Betadine
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• Comfeel
• Tegasorb
• Regranex