The Real Dangers of Synthetic Drugs in The 21st Century

1
The Real Dangers of Synthetic Drugs in The 21st
Century

• Ken Dickinson, M.S., R.Ph.
• kdickinson_at_gaudenzia.org
• 610-291-3109

2
Introductions

• Presenter
• Ken
• Attendees
• Experience with Bath Salts and K2/Spice
• Expectations or goals for this workshop

3
Objectives

• Describe the current trend of synthetic drugs
  of abuse being marketed as legal household
  products
• Identify the compounds referred to as bath
  salts and K2/synthetic marijuana 
• Demonstrate the effects on users with emphasis
  on the high incidence of psychosis
• Review the legal aspects and current
  legislation aimed at regulating and limiting
  access to these chemicals
• Discuss prevention and treatment approaches

4
Please Take Note

• Very little science
• Very little research
• Now accumulating data science
• Todays information anecdotal
• Face to face with users, Law Enforcement, etc
• Forums discussions on web
• Some research

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Designer Drugs Background

• Trend started in late 1970s
• Drugs of abuse are classified by DEA
• Drugs of abuse work according to structure
• Analogs
• Can design an analog to have same or similar
  activity but not listed as a controlled
  substance
• Not subject to legal penalties and restrictions

7
Mephedrone Methamphetamine
8
Designer Drugs Evolution

• Internationally do not have such laws
• Being manufactured in other countries
• Many designer drugs do not test ()
• A way to Beat the Bladder Police

9
Designer Drugs

• Todays trend
• Make an analog that is not listed in laws
• Since legal can make an distribute as an everyday
  household product e.g. Bath Salts Plant
  Food, potpourri, incense, jewellery cleaner,
  hummingbird attractant, etc.
• Then label not for human consumption
• Market via social media and retail outlets

10
European Drug Monitoring

• 24 new psychoactive drugs 2009
• 41 in 2010
• 49 in 2011
• 57 in 2012
• Since 2012 more than one a week
• Synthetic cathinones synthetic cannabinoids
  make up more than 2/3 of new drugs

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ResearchChemicals

• Schematic highlighting the major families and
  subfamilies of research chemicals, and some of
  their most prominent members.

12
Phenylethylamines I Have Known Loved

• Alexander Shulgin Ann Shulgin
• Book PiHKAL A Chemical Love Story (1991)
• Lists 179 psychoactive compounds
• A prerequisite to the psychedelic experience
• The book is arranged into two parts
• A fictionalized autobiography of the couple.
• Detailed synthesis instructions for over 200
  psychedelic compounds (most of which Shulgin
  discovered himself), including bioassays,
  dosages, and other commentary.

13
Historical Background

• All drugs of abuse started out as legal
  (uncontrolled) substances in US
• Heroin, LSD, Cocaine, Amphetamine, Marijuana and
  MDMA (ecstasy)
• Many sat on the shelf for years before becoming
  abused
• A mixture of rumor, myth and science have all
  contributed to changes in the legal status of
  these substances

14
Web Sites

• www.k2info.org
• www.bluelight.ru
• www.drugs-forum.org
• www.erowid.org
• www.lycaeum.org

15
K2 Products
16
Description of the Drug

• Mixture of herbal and spice plant products
• Leaf can be marshmallow leaf, parsley, etc.
• Sprayed with synthetic cannabinoids
• Marketed as incense and not for human
  consumption
• No regulations to list ingredients or age
  requirements to purchase
• First generation called K2 or Spice
• Second generation called K3 or Splice

17
Synthetic Marijuana (JWH- 018)

• K2 originated at Clemson University, where
  researchers developed synthetic cannabinoids in
  an effort to create therapeutic drugs. But the
  cannabinoids also have effects akin to THC, the
  key ingredient in marijuana
• K2 is largely created by individual sellers, it's
  anyone's guess what else is added to the mix.

18
Synthetic Cannabinoids Pharmacology

• Research supported by NIDA-John W.Huffman
• Two cannabinoid receptors in human brain CB1 and
  CB2
• CB2 affects inflammatory pain (target of NIDA
  study)
• JWH analogs target both receptors
• Huffman JWH is easiest to make outside of a lab
  only need two commercial products
• Transferring to plant material only requires
  using acetone

19
Any Dangers Involved in Spice/K2 Use?

• Yes. Until a drug is tested, it cannot be
  considered safe. Not only have synthetic
  cannabinoids not been tested, nearly all were
  created for experimental use in animals and cell
  cultures, not tested for use in humans.
• JWH-018 inventor John W. Huffman, PhD, puts it
  bluntly "It is like Russian roulette to use
  these drugs. We don't know a darn thing about
  them for real."
• These synthetic cannabinoids have been associated
  with impaired driving incidents, attempted
  suicides, and emergency department visits, and
  have been linked to such adverse effects as
  increased anxiety, panic attacks, heart
  palpitations, respiratory complications,
  aggression, mood swings, altered perception, and
  paranoia.

20
Dangers Involved in K2

• Recent reports (Jan 2013) of kidney failure
• Reports of cardiac events such as heart attack in
  young male users
• Medical reports indicate that K2/Spice drugs
  potentially result in users developing a rapid
  and powerful addiction on a level not usually
  found among smokers of real marijuana.

21
Teens K2 Effects in ER

• One 16-year-old girl was catatonic, unable to
  speak or respond to any touch, when she arrived
  in the emergency room. A urine drug test showed
  she had cannabinoids in her system.
• Another teen, a 16-year-old boy, had problems
  with movement and trouble with his speech.
  Although he was alert, he seemed confused, and
  could only answer simple questions.
• And an 18-year-old boy was brought to the
  emergency room agitated and excessively sweating.
  He was restless, aggressive and uncooperative.

22
Alarming Fact

• Tests show that even the same brand may have
  different drugs in different amounts-at
  different times
• User has no way of knowing what or how much they
  are taking

23
K2 Data

• American Association of Poison Control Centers
• Reported in article June 2012
• Year 2010 2, 906
• Year 2011 6,959
• Year 2012 5,205

24
Spice is typically smoked like marijuana
25
On Line Reported K2 Effects

• Strong dysphoria-Panic attacks-Heavy body
  load-Extreme nausea -Fear, Panic,
  Anxiety-Strong aural hallucinations--Racing
  heart (higher doses)
• Heart attack

26
On Line Reported K2 Effects

• Self mutilation
• Paranoia
• Auditory visual hallucinations
• Delirium
• Agitation

27
On Line Reported K2 Effects

• Marijuana-like effects
• Euphoria
• Giddiness
• Silliness
• Impaired short-term memory and concentration
• Increased appetite

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K2 Products
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Scooby Snacks K2
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What Are Spice Users Saying?

• But when I smoked this sonic boom stuff, I was
  completely high. I was trippin for over an hour.
  Its insane but fun. I got to the point where my
  vision kept zooming in and out.
• But I do not recommend this drug if you are a
  first time smoker or you dont like weed. This
  stuff gives you an intense head high, thus
  starting to trip and having hallucinations.
• This is very similar to the marijuana high but
  just a bit stronger. The only bad thing about
  this is that it is very bad for you because its
  an incense.

Source Various Blog Sites
39
What Are Spice Users Saying?

• Spice is nowhere near as dangerous as some people
  say it is.
• Sure its in no way good for you and it would
  kill you from the carcinogens eventually but
  thats about it.
• If youre responsible and just smoke a little
  every now and again youre not going to die and
  youre definitely not going to get addicted.
• I have literally taken a drug test the day after
  smoking it and passed no problem.

Source Various Blog Sites
40
Why the Discrepancy in Reports?

• Use of other drugs with incense
• Varying potency
• Overdose
• Presence of different cannabinoids
• Knock-offs
• User/environment characteristics
• Set setting, etc.

41
Spice Withdrawal

• Unrest Agitation
• Anxiety Panic Attacks
• Tremors
• Heart Palpitations
• Nausea Vomiting

• Sweating
• Nightmares
• Cravings
• Depression

42
K2 Treatment Issues

• High rates of addiction (K2info.org)
• Withdrawal due to physical addiction
• Treated with sedatives and clonidine
• Before DA treatment need to be medically and
  psychiatrically safe and stable
• Residual effects for weeks (or months) due to
  long half-life fat storage
• Unpredictable

43
K2 Testing

• Many labs have a test for the first generation
  JWH chemicals
• In February 2010, Redwood Labs, California
  developed a saliva test for JWH-018, JWH-073 and
  JWH-250
• Saliva and urine tests recently developed for
  second generation JWHs
• http//www.redwoodtoxicology.com/documents/service
  s/3369_sc_sellsheet.pdf

44
K2 Testing

• Following a single low dose exposure, synthetic
  cannabinoids can be detected up to 72 hours in
  human urine.
• In case of chronic exposure the window of
  detection is much longer
• http//www.redwoodtoxicology.com/services/syntheti
  c_cannabinoid_testing.html

45
When Done Right, Drug Testing Works!

• Traditional lab-based drug testing methods work
  at detecting synthetic marijuana, including
• Urine
• Oral fluid
• However, the lab will not conduct a traditional
  test for THC its a different test to detect
  chemical structure of synthetic marijuana but it
  can be detected with lab-based oral fluid and
  urine.
• So far, no evidence that instant urine testing
  devices, including products marketed as home
  drug test kits, work at detecting synthetic
  marijuana.

46
Then Came Oral Fluid Testing

• Well, its not urine
• Easy to administer internally
• Virtually impossible to adulterate
• Legal in most jurisdictions
• Legally defensible
• Rapidly increasing in popularity

47
Oral Fluid Testing

• Drugs are detected immediately after use
• Under the influence indicator
• Less invasive collection process
• Comparable to blood
• Science continues to progress and get better
• Flexible sample can be collected any time,
  anywhere
• There are FDA cleared oral fluid collection and
  testing products (for laboratory based testing)

Source Myths Facts About Oral Fluid Drug
Testing, On File OraSure Technologies, 3/2011
48
Cheating

• Urine tests are susceptible to drug test cheating
• Oral fluid is very difficult to adulterate
• Collection takes place in the presence of both
  the donor and the administrator of the test
• Typical cheating methods such as switching
  samples or adding something to a sample are
  virtually impossible to successfully pull off
• A search of the Internet will find thousands of
  hits for cheating on a urine drug test only a
  handful for oral fluid testing

49
Cheating

• A good website for oral fluid drug test cheating
  is wikihow.com/pass-a-drug-test. Quoting directly
  from the website
• Try to avoid the test. If one is being tested
  and has used in the past 3 days you will need to
  overcome the saliva collection. To do this you
  will have to avoid submitting saliva and perform
  the steps requested of you by the instructor.
  Another offers this advice
• To pass this an oral fluid test you should
  always know the detection time of the drug you
  have taken. Marijuana can be detected via saliva
  drug testing from an hour after ingestion up to
  24 hours depending on use. Between these periods
  of time, you must avoid being screened or you
  will surely test positive.

50
Dignity
The testing process protects the dignity and
privacy of the donor.

• No urine, no bathroom no humiliating observed
  collections, no gender match-up issues, no
  threats of drug test cheating
• Donor and administrator observe the collection
  together
• Specimen never leaves the donors sight
• Embarrassing shy bladder issues are eliminated
• Theres virtually no way to cheat

51
Testimonials

• We find the ability to test quickly and to
  collect the sample with minimal exposure to staff
  is a great advantage.
• -- Janet Ward, Former Drug Court Coordinator,
  Anne Arundel County (MD) District Court
• We are a very client-focused program and oral
  fluid testing allows us to concentrate on
  building the relationship rather than on drug
  testing.
• -- Keith Spare, Former Director of Rodgers South
  Drug Treatment, Kansas City, MO
• Intercept is more sensitive to patients needs
  by being less embarrassing and easier for
  patients to provide an oral fluid sample compared
  to that of urine.
• -- Dr. Beny Primm, Addiction Research Treatment
  Corp, New York City

52
OraSure Intercept

• Intercept Oral Fluid Collection Device
• Oral Fluid Drug Assays Used in Laboratory

53
K2 Overview

• No quality control
• Manufacturing process may be associated with
  adverse effects
• Subjective effects most closely resemble those of
  very powerful marijuana
• Almost complete lack of scientific study
• Street information very inconsistent

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Mitragyna Speciosa

• Used in
• Malaysia
• Thailand
• Indonesia
• Local names
• Ithang
• Biak Biak
• Ketum
• Kakuam

56
Kratom Pharmacology

• Mitragynine
• Structurally similar to some hallucinogens
• No hallucinogenic activity or effects
• Acts on opioid receptors

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Kratom Opioid Treatment

• Currently used for heroin and methadone
  dependence in some countries
• New Zealand
• Thailand
• Used in detox to manage withdrawal symptoms from
  opioids
• Millenium Labs announced test Aug. 2012

59
Kratom Opioid Treatment

• www.bluelight.ru
• Forum with much Kratom info
• Participants using Kratom to week off of oxy,
  heroin, Bup, etc.
• Majority unable to ween off of Kratom
• Descriptions of withdrawal
• Descriptions of how to prepare dosage
• Descriptions of which to buy and where

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Kratom

• Seems to be a stimulant in lower doses
• Mitragynine
• Seems to be sedative in higher doses
• 7 hydroxymitragynine
• Often produces a mixed effect
• Onset 5 t o 10 minutes
• Duration several hours

62
Kratom Side Effects

• Short term (immediate)
• Dry mouth
• Increased or decrease urination
• Loss of appetite
• Nausea and/or vomiting
• Side effects
• Anorexia/weight loss
• Depression
• Addiction

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Kratom

• EFFECTS
• Kratom is often described as producing
  simultaneous, contradictory effects- both an
  opiate-like sedation and coca-like stimulation.
  The stimulating effects tend to predominate at
  low dose levels, which may cause alertness,
  energy, and mild euphoria. Higher level doses are
  usually more tranquilizing, causing an
  opiate-like dreamy effect. Excessive doses can
  cause severe nausea. As with opium, it is known
  for causing constipation, and is sometimes used
  as a treatment for diarrhea.
• Onset
• When taken orally, the effects of kratom usually
  become noticeable in 15-20 minutes and clearly
  apparent in 30-60 minutes. Strong doses tend to
  have a more quicker, more dramatic onset.
• Duration
• A moderate dose of kratom may cause strong
  effects that last 2-4 hours, with residual
  effects lasting hours longer.

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Kratom

• Visual Effects
• Some visual effects have been reported, including
  both open-eye and closed-eye effects. Effects
  reported include wavering, shifting, and strobing
  in the visual field. There was also some
  patterning with eyes closed, as well as increased
  closed-eye visualizations.
• PROBLEMS
• Kratom is not known to be toxic, but can cause
  unpleasant symptoms at high doses such as nausea
  and vomiting. Regular use can lead to physical
  dependency. Kratom use can cause constipation
  similar to that caused by opiates. Chronic heavy
  use is reported to cause darkening of skin,
  insomnia, dry mouth, and anorexia.
• Addiction Potential
• There are reports of physical dependency after
  frequent, heavy kratom use. Individuals who use
  it regularly or in large doses may have trouble
  quitting. Withdrawal symptoms include
  irritability, yawning, diarrhea, runny nose, and
  pain in the joints or muscles.
• http//www.bing.com/videos/search?qYouTubeKrato
  mviewdetailmidEC48A0AFEDFBEA20762AEC48A0AFEDFB
  EA20762Afirst0FORMLKVR16

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  price. This powdered Mitragyna speciosa leaf is
  high alkaloid like the previous product but has
  it's own unique mix of alkaloids. It is superior
  to the young, cultivated leaf material which
  copycat sellers have tried to sell, and of course
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Kratom E-Cigarettes

• KratomiteAdventure Industries' Kratomite is the
  world's first electronic cigarette to deliver
  Kratom, a medicinal herb known for its
  concentration of alkaloids, according to the
  company. Kratom interacts with opioid receptors,
  which may offer users relaxing sensations. Unlike
  tobacco-alternative electronic cigarettes,
  Kratomite is a personal vaporizer that uses a
  proprietary, herbal-infused formula, said the
  maker. Adventure IndustriesPembroke Park, Fla.
  [phone], ext. 1287sales_at_adventureindustri
  es.com

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Mephedrone(4-Methylmethcathinone)
69
Bath Salts

• Toxic psychoactive drugs disguised or
  pretending to be Bath Salts
• They are NOT
• Some people have snorted real BSs

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Bath Salts Are
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Khat

• Native to tropical East Africa and the Arabian
  Peninsula
• Fresh Leaves/tops chewed or consumed as tea
• Stimulation and euphoria
• Part of social culture in many countires (coffee,
  tea, coca or khat)

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Khat

• Coca ---------------cocaine
• Khat ----------------cathinone (Schedule I)
• Cathinones Structure similar to amphetamines
• Euphoria
• Anorexia
• Stimulation
• Dilated pupils
• Hypnagogic hallucinations when wearing off

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What are Synthetic Cathinones?

• Synthetic cathinones are related to the parent
  compound cathinone.
• Since the mid-2000s, unregulated ring-substituted
  cathinone derivatives have appeared in the
  European and American recreational drugs market.

74
What are Synthetic Cathinones?

• The most commonly available synthetic cathinones
  sold on the recreational market in the period up
  to 2012 appear to be 3, 4-Methylenedioxypyrovalero
  ne (MDPV), mephedrone, and methylone.
• These products are usually encountered as highly
  pure white or brown powders. Cathinone
  derivatives are claimed to have effects similar
  to those of cocaine, amphetamine or MDMA
  (ecstasy), but little is known of their detailed
  pharmacology.

75
Mephedrone Background

• Discovered 1929
• Rediscovered 2003 web site The Hive
• Was a replacement for Ecstasy
• Sold as plant food later bath salts
• Manufactured in clandestine labs
• Methylenedioxypyrpvalerone (MDPV)
• Known as substituted cathinones

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MDPV Timeline

• MDPV was developed in the 1960s, and has been
  used for the treatment of chronic fatigue, but
  caused problems of abuse and dependence.
• 1969 Boehringer Ingelheim files a patent
  application for MDPV.
• 2005 MDPV appears as a recreational drug first
  mention on Drugs-Forum.
• 2007 First seizure of MDPV as a recreational
  drug, by customs officials in the German state of
  Saxony. The drug had been shipped from China.
• 2008 First seizure of MDPV in the United States.
  

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MDPV Timeline

• 2009 MDPV made illegal in Denmark.
• 2010 MDPV made a controlled drug in the UK,
  Sweden, Germany, Australia and Finland. First
  reports of the widespread retail marketing of
  'bath salts' containing MDPV in the US. The US
  considers both Mephedrone (July, 2010) and MDPV
  (December, 2010) "a drug and chemical of
  concern".
• 2011 2012 MDPV sale and possession are banned
  in most US states with legislation being
  introduced in Maryland and other states.

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Bath Salts (Cathinones) Appearance

• Distinctive odor
• Fishy
• Vanilla
• Stale urine
• Bleach
• Circuit boards

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Cathinones Use

• Capsules, tablets or white granuels
• Can be swallowed, smoked, snorted, injected
• Prominent use in Europe
• Out of 70 Dutch users of mephedrone, 58 described
  it as an overall pleasant experience and 12
  described it as an unpleasant experience

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Cathinones Effects

• Duration
• Total 2 5 hours
• Onset 15-45 minutes
• Coming up 15 30 minutes
• Plateau 15 30 minutes
• Coming down 30 90 minutes
• After effects 2 4 hours

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Cathinones Desired Effects

• Mental and physical stimulation
• Euphoria, mood lift
• Feelings of empathy, openness
• Increase in sociability, desire to talk with
  others
• Pleasurable rushing
• Sense of being sped up

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Cathinones General Effects

• General change in consciousness (as with most
  psycho-actives)
• Decreased appetite
• Pupil dilation
• Unusual body sensations (facial flushing, chills,
  goose bumps, body energy)
• Change in body temperature regulation
• Sweating
• Increase in heart rate and blood pressure

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Cathinones General Effects

• Sleep deprivation
• Bruxism
• Motor automatisms (compulsive repeated hand
  washing)
• Hyper-alertness

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Cathinones Toxic Effects

• Strong desire to re-dose, craving to recapture
  initial euphoric rush
• Uncomfortable changes in body temperature
  (sweating/chills)
• Heart palpitations, sense of racing heart
• Impaired short term memory
• Insomnia
• Skin lesions (?)

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Cathinones Toxic Effects

• Severe paranoia
• Psychosis (Excited Delirium)
• Hypersexuality
• Aggression
• Hallucinations
• Anxiety and depression
• Seizures

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Bath Salt Data

• American Association of Poison Control Centers
  of calls
• June 9, 2012 report
• Year 2010 304
• Year 2011 6,138
• Year 2012 2,656
• Year 2013 Jan-April 350

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Cathinones Treatment Issues

• Similar to strong amphetamine addiction
• Similar to PCP abuse/addiction
• Non-psychotic withdrawal use Benzos
• Stabilization and Safety highest priority
• Safety of client
• Safety of staff and others

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Cathinones Treatment Issues

• If psychotic or dissociated need to medicate
• Neuroleptics
• Haldol for emergency stabilization
• Atypicals (Seroquel/Respirdol/etc.) for ongoing
  stabilization
• Decease sensory exposure
• Rock or Rave medicine
• Talking down bad trips
• De-escalation techniques

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Cathinones Treatment Issues

• Once stable and safe be aware of cognitive
  impairment
• May need tincture of time to grasp recovery
• Supportive non threatening environment
• Screen for COD (high probability)
• Buproprion for concurrent depression

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Synthetic Cathinones Effects Summary Sheet

• Aggression
• Agitation
• Breathing difficulty
• Bruxism (grinding teeth)
• Confusion
• Dizziness
• Extreme anxiety sometimes progressing to violent
  behavior
• Fits and delusions
• Hallucinations
• Headache

• Hypertension (high blood pressure)
• Increased alertness/awareness
• Increased body temperature, chills, sweating
• Insomnia
• Kidney pain
• Lack of appetite
• Liver failure
• Loss of bowel control
• Muscle spasms
• Muscle tenseness
• Vasoconstriction (narrowing of the blood vessels)
  

• Nausea, stomach cramps, and digestive problems
• Nosebleeds
• Psychotic delusions
• Pupil dilation
• Renal failure
• Rhabdomyolysis (release of muscle fiber contents
  myoglobin that could lead to kidney problems)
• Severe paranoia
• Suicidal thoughts
• Tachycardia (rapid heartbeat)
• Tinnitus

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Synthetic Drug Abuse Prevention Act of 2012

• July 10, 2012 President signed Law making
  temporary law permanent
• October 1, 2012 Synthetic Drugs now listed as
  Schedule I
• All substituted cathinones now Schedule I
• Chemists working on making non-cathinone
  stimulants
• http//www.ncsl.org/issues-research/justice/synt
  hetic-drug-threats.aspx

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Prevention For K2 Bath Salts

• Heighten awareness via Education
• Schools, parent groups, community groups, law
  enforcement, medical treatment, etc.
• Legislation against precursor chemicals
• Legislation making drugs Schedule I
• Patrick Meehan Synthetic Drug Control Act
• Goes into effect October 1, 2012!!!
• Hit the retailers in their pocket book
• Civil suits by victims (users and families)
• Authorities appealing to retailers with amnesty
  if stop and destroy

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Urine Detection Information

• Redwood Toxicology Laboratory shows currently
  they have detection for MDPV and Mephedrone. (see
  w.K2info.org/drugtesting)
• June 11, 2012 Redwood expanded to test for 21
  designer stimulants
• http//www.redwoodtoxicology.com/services/designer
  _stimulant_testing.html
• Atlantic Labs- Bensalem, PA Bath Salts 20.00 and
  K2 15.00.
• Most labs now testing
• Check with your lab

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On-Site Testing

• Many labs now have available
• On site urine may be useful in treatment
• Problem labs report as high as 35-40 false
  negatives with on-site.
• On-site shows no use but when testing for
  accuracy they send to lab for confirm and up to
  40 tested positive
• Saliva test available

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2C-1 or Smiles

• Reports now in Mid-Atlantic states (Sept 2012)
• Prevalent on YouTube (users)
• Similar to a mix of ecstasy LSD but with longer
  high higher potency than either
• Unusual unpredictable effects
• Not detectable like bath salts
• Potency not consistent from batch to batch

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2C-1 or Smiles

• Usually sold in white powder form and can be
  melted into chocolate candy, but can also be
  taken as a tablet
• Also sold as breath mint or drops
• Both a hallucinogen and a stimulant- has been
  linked to recent teen deaths
• Can cause heart to beat out of control, seizures
  and foaming at the mouth

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Krokodil

• Opioid- desomorphine
• Result of attempt to extract codeine
• Injected can be used by other routes
• Russia spreading through Europe
• Tissue breakdown
• Highly addicting- Usually fatal

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Desomorphine

• 8-10 X more potent than morphine
• First discovered in 1932
• Sedative opioid effects
• Made from codeine, red phosphorous Iodine
  (similar to methamphetamine)
• Made in 30 minutes injected immediately
• Produces gangrene phlebitis

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Mollys

• Pure molecule of MDMA
• Popular in rap music lyrics
• Used at parties and raves
• Lately Mollys have contained cathinones
• Familiar effects of XTC
• Bruxism, hyperthermia, anxiety, depression,
  dehydration, etc

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Salvia divinorum

• Regulated in PA
• Legal for over 21 y.o. in MD
• Not regulated by Feds
• Dissociative effects
• Visions and hallucinations
• Purchased on internet or locally
• Most potent hallucinogen mg by mg
• Smoked

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Benzo Fury

• 6- APB
• Entactogenic phenylethylamine
• Not scheduled and not approved for human
  consumption by FDA
• Use is rapidly on rise
• Number of websites selling on the rise
• Sold as research chemical

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Benzo Fury

• Effects including both positive and negative
  ones.Increased happiness, euphoria, extreme mood
  lift, increased self-acceptance, feelings of a
  peace and love toward others, increased intimacy
  and closeness with others, closed-eye
  hallucinations, ability to discuss topics with
  others that would not normally be discussed,
  pleasurable body rushes, increased sexual
  interest,

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Weed Oil or Honey

• Recent resurgence
• Butane method popular
• Fires explosions
• Solvent with heat extracts the THC
• 30 and higher THC
• Recipes cook books on web
• YouTube demonstrations

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Weed Oil or Honey

• Onset of action longer 45 to 60 minutes
• Duration of action 6 hours and maybe longer
• Intensity of high greater due to high THC
• Can also be smoked
• Vaporizers used

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Weed Oil or Honey

• Edible Marijuana
• Ice Cream

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Points to Ponder

• WHAT
• Did I learn today?
• What do I think about it?
• How do I feel about it?
• So WHAT
• Does this information mean to me professionally
  and personally?????