Dr. Fabio de Sousa Menezes works with the discovery of new leads from medicinal plants (intact species) from Ireland, South America, Serbia and Thailand, aiming among other things, to achieve the isolation and validation of new compounds against several

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Dr. Fabio de Sousa Menezes works with the
discovery of new leads from medicinal plants
(intact species) from Ireland, South America,
Serbia and Thailand, aiming among other things,
to achieve the isolation and validation of new
compounds against several different
pharmacological targets. The idea can start with
any ethnopharmacological information and the goal
is to finish with the pharmaceutical development
of new products. His work is in the field of
Applied Pharmacognosy and his research is under
the NPDD group interests.Natural Products as a
Source for Drug Discovery. In TCD the
fundamental goal of the research in the Natural
products Drug Discovery Group (NPDDG) is the
isolation of new chemical entities and the
evaluation of their pharmacological activity and
potential as new therapeutic agents for a range
of diseases.  Natural Product Drug Discovery
Group Dr. Helen Sheridan (HS), Mrs Ingrid Hook
(IH), Dr. John J. Walsh (JJW), Dr. Neil Frankish
(NF), Dr. Fabio de Sousa Menezes (FdeSM), Ciara
Smyth (CS) (Research associate).

• FdeSM Research Interests
• Evaluation of essential oil-containing plants
  against bacteria, fungi and different cancer
  types.
• Evaluation of medicinal plants leading to the
  isolation and identification of compounds used
  for the treatment of different types of cancer.
• Evaluation of medicinal plants leading to the
  isolation and identification of compounds used
  for the treatment of diabetes.
• Evaluation of medicinal plants leading to the
  isolation and identification of compounds bearing
  anti-virus activity.
•  

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CollaborationsNational Dr. Helen Sheridan
SchoolofPharmacyandPharmaceuticalSciences
TCD.Dr. Neil Frankish - SchoolofPharmacyandPharma
ceuticalSciences TCD.Dr. Carlos Medina -
SchoolofPharmacyandPharmaceuticalSciences
TCD.Dr. Lidia Tajber SchoolofPharmacyandPharmac
euticalSciences TCD.Dr. John
ParnellDepartmentofBotany TCD.Dr. Graham
PidgeonSchoolof Medicine TCD.Dr.
FionaWalshSchoolof Medicine TCD.
InternationalDr. Carla Holadino Quaresma
FacultyofPharmacy FURJ Brazil.Dr. Davyson de
Lima Moreira Oswaldo Cruz Foundation RJ
Brazil.Dr. Elis Eleutherio DepartmentofBiochemi
stry FURJ Brazil.Dr. Celuta Sales Alviano
DepartmentofMicrobiology FURJ Brazil.Dr.
Daniela Sales Alviano DepartmentofMicrobiology
FURJ Brazil.Dr. FrancoiseNiellout
FacultyofPharmacy MontpellierUniversity
France.Dr. LauranceVian FacultyofPharmacy
MontpellierUniversity France.Dr. PatriciaDias
Fernandes DepartmentofPharmacology FURJ
Brazil.Dr. Maria Eline Matheus
DepartmentofPharmacology FURJ Brazil.Dr.
Nunziatina di Tommasi FacultyofPharmacy
Salerno Italy.Dr. NikoRadulovic
DepartmentofChemistry UniversityofNis Serbia.

• Recent Publications
• 1- C.G. Silva, R.J. Raulino, D.M. Cerqueira, S.C.
  Mannarino, M.D. Pereira, A.D. Panek, J.F.M.
  Silva, F.S. Menezesand E.C.A. Eleutherio. In
  vitro and in vivo determination of antioxidant
  activity and mode of action of isoquercitrin and
  Hyptisfasciculata. doi10.1016/j.phymed.2008.12.01
  9.
• 2- RennoMN., Barbosa GN., Zancan P., Veiga VF.,
  Alviano CS., Sola-PennaM., Menezes FS.,
  HolandinoC . Crude ethanol extract from babassu
  (Orbignya speciosa) cytotoxicity on tumoral and
  non-tumoral cell lines. Annals of the Brazilian
  Academy of Science, 80(3) 467, 2008.
• 3- Falcao DQ., Costa ER., Kuster RM., Nielloud
  F., Vian L., Menezes FS. Evaluation of
  cytotoxicity, phototoxicity and genotoxicity from
  Calceolaria chelidonioides (Scrophulariaceae)
  flowers ethanol extract . PlantaMedica, 73(9)
  973, 2007.
• 4- Falcao DQ., Costa ER., Kuster RM., Nielloud
  F., Vian L., Menezes FS. The obtention of an
  oil/water nanoemulsion containing the Calceolaria
  chelidonioidesflowers ethanol extract and its
  skin hydration power. PlantaMedica, 73(9) 1018,
  2007.
• 5- MatheusME., Fernandes SBD., Silveira CS.,
  Rodrigues VP., Menezes FS., Fernandes PD.
  Inhibitory effects of EuterpeoleraceaMart. on
  nitric oxide production and iNOSexpression.
  Journal of Ehtnopharmacology, 107(2) 291, 2006.
• 6- Silva CG, Herdeiro RS, Mathias CJ, Panek AD,
  Silveira CS, Rodrigues VP, Renno MN, Falcao DQ,
  Cerqueira DM, Minto ABM, Nogueira FLP, Quaresma
  CH, Silva JFM, Menezes FS, EleutherioECA.
  Evaluation of antioxidant activity of Brazilian
  plants. Pharmacological Research, 52(3) 229,
  2005.
• 7- Matheus ME, Berrondo LF, Vieitas EC, Menezes
  FS, FernandesPD. Evaluation of the
  antinociceptive properties from Brillantaisia
  palisotii Lindau stems extracts. Journal of
  Ethnopharmacology, 102(3) 377, 2005.