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Lymphoma

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Lymphoma Dr. Raid Jastania Dec 2006 By the end of this session you should be able to: Discuss the basis of the classification of lymphomas Know the different stages ... – PowerPoint PPT presentation

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Title: Lymphoma


1
Lymphoma
  • Dr. Raid Jastania
  • Dec 2006

2
  • By the end of this session you should be able to
  • Discuss the basis of the classification of
    lymphomas
  • Know the different stages of B lymphocyte
  • List common genetic abnormalities in lymphomas
  • Classify Hodgkin lymphoma and the difference
    between the subtypes

3
Lymphoma
  • Classification WHO
  • Lymphoid, Myeloid, Histiocytic
  • Definitions
  • Precursor, mature, stage of differentiation,
    naïve, peripheral, small cell, large cell
  • CDs
  • Common types Follicular lymphoma, Diffuse large
    B cell lymphoma
  • Age
  • Non Hodgkin 6th- 7th decade
  • Hodgkin 3rd decade

4
(No Transcript)
5
  • Risk factors
  • Abnormalities in the immune system.
  • EBV
  • HHV8
  • Hepatitis C virus
  • H. pylori

6
The Journey of the B cells
Bone marrow
Peripheral blood
Lymph node
7
The Journey of the B cells
  • Bone marrow- Blast- VDJ gene rearrangement-
    mature naïve Ig positive cells- IgM, IgD, CD5
  • Antigen- transformation- proliferation- mature B
    cell IgM
  • Germinal center maturation, Somatic mutation.
  • IgG, IgA plasma cells and memory cells.
  • Plasma cells- bone marrow

8
The Journey of the B cells
  • Bone marrow- Blast- VDJ gene rearrangement-
    mature naïve Ig positive cells- IgM, IgD
  • CD20, CD19,CD10, TdT, CD5/-
  • Antigen- transformation- proliferation- mature B
    cell IgM
  • CD20, CD10, Bcl-2
  • Germinal center maturation, Somatic mutation.
  • CD20
  • IgG, IgA plasma cells and memory cells.
  • Loose all the B cell markers CD138
  • Plasma cells- bone marrow

9
The Journey of the B cells
Bone marrow
Peripheral blood
Lymph node
10
Genetics
  • Follicular lymphoma t(1418)
  • Bcl-2 over expression
  • Mantle cell lymphoma t(1114)
  • CyclinD1 over expression
  • Burkitt lymphoma t(814)
  • C-myc over expression

11
Classification
  • Based on
  • Morphology
  • Immunophenotyping
  • Clinical presentation
  • Molecular/cytogenetic findings

12
Classification
  • Predominantly disseminated lymphoma/Leukemia
  • Primary extranodal
  • Primary nodal

13
Classification
  • Predominantly disseminated lymphoma/Leukemia
  • CLL, lymphoplasmacytic lymphoma, Myeloma
  • Primary extranodal
  • Marginal zone lymphoma
  • Primary nodal
  • Follicular lymphoma, mantle cell lymphoma
  • Aggressive types
  • Diffuse large B cell lymphoma, Burkitt lymphoma
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