Cognitive Aging Summit II Epigenetics of age-related cognitive change: Perspectives, puzzles and prognostications

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Cognitive Aging Summit IIEpigenetics of
age-related cognitive changePerspectives,
puzzles and prognostications

• Peter R. Rapp
• Laboratory of Experimental Gerontology
• National Institute on Aging

no conflicts
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Translation to neurocognitive aging
Challenges Cognitive considerations
Temporal dynamics of epigenetic modification
Intervention
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Translation to neurocognitive aging
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Translation to neurocognitive aging
From Peleg et al. (2010) Science
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Current perspective
Learning and Memory
Epigenetic Modification
Synaptic Plasticity
Gene Transcription
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Translation to neurocognitive aging
From Peleg et al. (2010) Science
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Bidrectional epigenetic modification in cognitive
aging
CA1
CA3
DG
Peleg et al. (2010) Science
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Emerging perspective
Learning and Memory
Epigenetic Modification
Synaptic Plasticity
Gene Transcription
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Implications for interventions
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acknowledgments
Laboratory of Experimental Gerontology Neurocogni
tive Aging Section Bonnie Fletcher James
Castellano Bennett Kelley-Bell David
Kim Jeffrey Long Ines Pereira Angila
Sewal Ed Spangler Evelyn Perez Min
Zhu Jennifer Young Terrence
Pleasant Collaborators Gallagher Lab National
Institute on Aging