BIOMIMETICS CHEMISTRY New Field in Chemistry Emerging from the Advancement of Biotechnology Workshop on The Establishment of BINASIA Indonesia Nodal 27-28 July 2005, Jakarta, Indonesia - PowerPoint PPT Presentation

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BIOMIMETICS CHEMISTRY New Field in Chemistry Emerging from the Advancement of Biotechnology Workshop on The Establishment of BINASIA Indonesia Nodal 27-28 July 2005, Jakarta, Indonesia

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Biomimetic techniques could also overcome stereochemical problems faced by conventional synthesis THANK YOU Lanosterol * * Title: BIOMIMETICS CHEMISTRY Author: – PowerPoint PPT presentation

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Title: BIOMIMETICS CHEMISTRY New Field in Chemistry Emerging from the Advancement of Biotechnology Workshop on The Establishment of BINASIA Indonesia Nodal 27-28 July 2005, Jakarta, Indonesia


1
BIOMIMETICS CHEMISTRYNew Field in
ChemistryEmerging from the Advancement of
BiotechnologyWorkshop onThe Establishment of
BINASIA Indonesia Nodal27-28 July 2005, Jakarta,
Indonesia
  • UMAR A. JENIE
  • Indonesian Institute of Sciences (LIPI)
  • Department of Medicinal Chemistry,
  • Faculty of Pharmacy, Gadjah Mada University (UGM)

2
BIOMIMETICS CHEMISTRY
  • Biomimetics chemistry is not Biotechnolgy, it is
    a new field in Chemical Sciences concerns with
    synthesizing product/s that could imitate
    (mimics) biological function and processes.
  • Development of biomimetics chemistry depends
    mainly in the advancement of molecular based
    biotechnology which elucidating biosynthetic
    mechanism of bio-products.

3
  • Molecular Biology
  • Mechanisms of Biological activities and
  • Biosynthesis mechanisms
  • Biomimetic Chemistry
  • Biomimetic Products Processes

4
  • BIOMIMETICS CHEMISTRY is a branch of chemistry
    that study on how to make products
  • Biomimetic Products (making products having
    function similar or identical to that of the
    biological products)
  • Biomimetic Processes (organic synthesis based on
    biosynthetic mechanisms)

5
BIOMIMETIC PRODUCTS
  • ARTIFICIAL BIOPRODUCTS
  • Example Artificial Hb
  • Organic chemists have been trying to construct
    and develop organic molecule that have capability
    to cacth up reversibly oxygen from the air,
    similar to that of the haemoglobine.
  • This molecule called
  • PICKET FENCE PORPHYRINS.

6
Haem binds oxygen reversibly
7
BIOMIMETIC PRODUCTPICKET FENCE PORPHYRINS
8
Oxygen will be trapped by thePorphyrins
9
BIOMIMETIC PROCESS
  • BIOSYNTHESIS PATHWAY
  • Organic chemists have been inspired by
    biosynthesis pathways of secondary metabolites
    occurred in nature. They are using such natural
    mechanism to construct natural products. Such
    approach known as Biomimetic Synthesis.

10
BIOMIMETIC PROCESSbased on Biosynthetic Mechanism
  • LANOSTEROL BIOSYNTHESIS
  • lanosterol biosynthesis proceeds via Mevalonic
    Pathway, in which the intermediate
    squalene-2,3-epoxide undergoes protonation,
    followed by MW rearrangement to produce
    lanosterol.

11
LANOSTEROL BIOSYNTHESIS
12
LANOSTEROL BIOSYNTHESIS
Lanosterol
13
Johnson constructed the triene compound to mimic
the natural squalene
14
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16
Johnsons Biomimetic Synthesis ofProgesteron
17
FUTURE DEVELOPMENT
  • Biomimetic techniques could be used for synthesis
    of a complex biological molecules, such as
    steroids, with shorter step of reactions than the
    conventional ones.
  • Biomimetic techniques could also overcome
    stereochemical problems faced by conventional
    synthesis

18
  • THANK YOU
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