Course of Immunology -introduction

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Course of Immunology -introduction

• Rudolf Horváth, Radek Špíšek, Tomáš Milota
• 2013
• email rudolf.horvath_at_fnmotol.cz
• radek.spisek_at_lfmotol.cuni.cz
• tomas.milota_at_fnmotol.cz

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Course structure

• ? Lectures
• Presence in lectures is obligatory
• Lectures are held every Tuesday at 800-940
• - Three absences are tolerated, more frequent
  absences must be based on official certificate
  and written thesis

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Date Theme Teacher
1.10. Immune system, overview. Phagocytic cells, complement. Communication between cells of immune systems, adhesion molecules, cytokines. prof. Špíšek
8.10. Antigen processing and presentation, HLA I and II class. prof. Šedivá
15.10. Specific (adaptive) immunity T and B lymphocytes PharmDr.Palich - Fucíková
22.10. Immunity against infection Adkins/Bartunková
29.10. Immunodeficiency, vaccination prof.Šedivá
5.11. Immunity against tumors. prof. Špíšek
12.11. Immunology of transplatation dr. Kalina
19.11. Autoimmunity. Immunopathology. dr. Kayserová
26.11. Immunopathological reactions, allergy dr. Kayserová
3.12. Immunotherapy dr. Podrazil
10.12. Clinical aspects of immune disorders prof. Bartunková
17.12. Case Reports
7.1.2014 Case Reports
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• ? Seminars
• - The first seminar is compulsory the time of
  other seminars is devoted to self-studying,
  preparation of seminar thesis and consultations
  with teachers.

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Seminar thesis

• ? groups of 1-2 students
• ? structure of thesis
• 1000 2000 words
• form of an essay
• briefly concisely interestingly
• Abstract, text and references (literature) are
  obligatory, subchapters are recommended
• ?Term of submission until 25.10.2013
• in the digital form
• - has to be sent to irena.novakova_at_lfmotol.cuni.
  cz

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• ? Topics of the seminar thesis
• Basic immunology
• Regulatory T cells - function and subtypes
• IL-17, its role in pathologic inflammatory
  process
• Immune homeostasis in the gut.
• Biology of NKT cells.
• Use of monoclonal antibodies in treatment of
  tumours.
• Modulation of the immune system by viruses.
•  
• Disorders of the immune system
• Immunology of sepsis
• Role of Toll-like receptors in autoimmune disease
• Role of mast cells in the induction of allergic
  diseases
• Periodic fevers- genetic background
• Immunology of coeliac disease.
• Genetic defects of Toll-like receptor signaling
  pathways
•  
• Immunotherapy
• IRAK-4 and MyD88 deficiency- pathophysiology and
  clinical presentation

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• ? Presentation
• each thesis will be presented verbally
• afterwards on 13.11 and 20.11.2013
• (Lecture hall, block G, 3rd floor)
• range 8 minutes
• Powerpoint presentation (6-10 slides)

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Citation
Most of the patients are hemizygous for 22q11.2,
some have defects in various loci on chromosome
10, about 10 of cases are familial (2, 3)

• Literature / References
• 2. DRISCOLL DA, SALVIN J, SELLINGER B, et al.
  Prevalence of 22q11 microdeletions in DiGeorge
  and velocardiofacial syndromes implications for
  genetic counselling and prenatal diagnosis. J Med
  Genet 1993 30 813-7.
• 3. SEDIVA A, BARTUNKOVA J, ZACHOVA R, et al.
  Early development of immunity in diGeorge
  syndrome. Med Sci Monit 2005 11 182-7.

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Final appraisal
? Presence on lectures ? Seminar thesis
fulfilled / not fulfilled
verbal appraisal (after
presentation) ? Verbal examination
2 out of 50 questions
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Evaluation of the essay 1/ Adherence to the
length limits 2/ Correct content of the essay, no
serious misunderstandings 3/ Satisfactory
graphical layout and style of the essay Other
comments Evaluation of the verbal
presentation 1/ Adherence to the length
limits 2/ Correct content of the essay, no
serious misunderstandings 3/ Satisfactory
graphical layout and style of the presentation
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Sources
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Pubmed Entrezwww.pubmed.com

• PUBMED
• BOOKS
• OMIM
•  
• Medline Plus
• http//medlineplus.gov/
•  
• TOXNET
• http//toxnet.nlm.nih.gov

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Google Scholar
http//scholar.google.com/
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Clinical sources on-line

• SumSearch
• http//sumsearch.uthscsa.edu/
• E-medicine
• http//www.emedicine.com/
• Up-to-Date
• http//www.uptodate.com/
• Current Controlled Trials
• http//controlled-trials.com/
• Orphanet
• http//www.orpha.net/

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http//imunologie.lf2.cuni.cz/
? shedules ? presentations (download
possible) ? recommended literature, links ?
contacts