High Incidence of Long Bone Dysplasia In Newborn Infants In Qatar

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High Incidence of Long Bone Dysplasia In Newborn
Infants In Qatar

• Y. Abu-Osba K. Salameh S. Khan M. Kayyali
• Neonatal Medicine Services, Jordan Hospital,
  Amman, Jordan
• Neonatology Section, Womens Hospital, Doha, Qatar

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High Incidence of Long Bone Dysplasia In
QatarEPIDEMIOLOGICAL AND CLINICAL
CHARACTERISTICS

• Total No. of live birth baby
  82.000 infants
  Qataris
  47Total NO. with long bone
  dysplasia 13(1.6/10,000)
  Qataris
  69.2 (9/13)Female male
  ratio
  6/7Mean gestational age (SD)
  373.1 wkLess than 37 wk.
  gestation
  4/13Mean birth weight
  2.610749 g Mean head
  circumference
  32.6 cmMean height
  46.9 cm 

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High Incidence of Long Bone Dysplasia In Qatar
MATERNAL FACTORS

•  
• Mean maternal age
  26.92 yearsNormal vaginal delivery
  11/13 (84.6)Parity 1.46 para
  /Mother Infants from multiple gestation 2
  (15.3/10,000)   

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High Incidence of Long Bone Dysplasia In Qatar
PREDISPOSING FACTORS

• Diabetes mellitus 6/ 13 53.8History of
  abortion 5/ 13 38.5History of consanguinity
  7 /13 61.5Mothers blood group O
  10/13 76.9History of drug intake
  2/13 15.3History of c.
  malformation 2/13 15.3 

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High Incidence of Long Bone Dysplasia In Qatar
Types of Dysplasia - 1

•  
• Total patients with absent / dysplastic long
  bones 13
• Absent - hypoplastic radius
  9/13
• Absent hypoplastic ulnae with or without radius
  5/13
• Isolated long bone dysplasia
  6/13
• ADLB with one or more associated anomalies
  7/13
•   

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High Incidence of Long Bone Dysplasia In Qatar
Types of Dysplasia - 2

•  
• Absent femur
  1/13
• Dysplasia of tibia fibulae
  2/13
• Upper limb Lower limb
  3.31
• Left upper limb Right upper limb
  2.51
• Bilateral
  5/13  

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High Incidence of Long Bone Dysplasia In Qatar
ASSOCIATED MAJOR CONGENITAL ANOMALIS

• Associated with heart disease
  5Associated with esophageal
  atresia 2Associated
  with hypoplastic kidney
  2Associated with hydrocephalus
  2Associated with sacral agenesis
  2Associated with
  cleft lip palate
  1Absent radii associated with absent thumb
  3/9Associated single umbilical artery
  3

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High Incidence of Long Bone Dysplasia In Qatar
SUMMARY

• Radius dysplasia incidence is 16 100,000
  compared to 1100,000 in literature.
• Associated with maternal diabetes 53.8 .
• Major multiple congenital anomalies are present
  in more than half of the cases.
• Observed increase of three of folds the incidence
  of long bones dysplasia in the last 4 years
  (1990-1994) compared to the period of 1986-1989.

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High Incidence of Long Bone Dysplasia In Qatar
Conclusion

• The incidence of long bones dysplasia in the
  newborns post the Gulf War increased by 4 folds
  in Qatar population compared to pre war period,
  and is much more common than the published
  literature . 
• The cause is not clear yet ...!!! ???

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High Incidence of Long Bone Dysplasia In Qatar
Recommendations

• Further detailed epidemiological studies are
  recommended in the region to clarify the cause
  for these priliminary observations.  

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Examples of Long Bone Aplasia / Dysplasia In
Newborn Infants In Qatar
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Examples of Long Bone Aplasia / Dysplasia In
Newborn Infants In Qatar
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Examples of Long Bone Aplasia / Dysplasia In
Newborn Infants In Qatar
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Examples of Long Bone Aplasia / Dysplasia In
Newborn Infants In Qatar
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Examples of Long Bone Aplasia / Dysplasia In
Newborn Infants In Qatar
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Examples of Long Bone Aplasia / Dysplasia In
Newborn Infants In Qatar
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Examples of Long Bone Aplasia / Dysplasia In
Newborn Infants In Qatar
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Examples of Long Bone Aplasia / Dysplasia In
Newborn Infants In Qatar
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Examples of Long Bone Aplasia / Dysplasia In
Newborn Infants In Qatar
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Examples of Long Bone Aplasia / Dysplasia In
Newborn Infants In Qatar
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Examples of Long Bone Aplasia / Dysplasia In
Newborn Infants In Qatar
Examples of Long Bone Aplasia / Dysplasia In
Newborn Infants In Qatar
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Examples of Long Bone Aplasia / Dysplasia In
Newborn Infants In Qatar
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Examples of Long Bone Aplasia / Dysplasia In
Newborn Infants In Qatar