FOOD TOXICOLOGY

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FOOD TOXICOLOGY
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? ? 021-55271117 caohuian_at_yahoo.com.cn
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???(toxicology)
toxic----???toxious(1655)
????toxikon(??)
toxon(??)
logy ----????logos(??)
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?????(Food Toxicology)

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???????(safety evaluation)

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• ??5000??(3000-2000B.C)???????3500????1500
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??Paracelsus????????????????,??????????????????,?
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???????(19??)
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• ?????Ramazzini??????????????????????????????,?
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• Orfila ????,????????(1815?)
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????50??????????????
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1930 1948 1956 1943 1955 1953 1968 1960 ??????? ?????? ???? ????? ????? ??????? ???? ???? SO2 /???/?? SO2????? SO2??? ????? ? ??? ???? SO2???? ?????? 6000????60? 6000????20? 4000???? ??1/2????? 400???? ??258?,?128? ??2000??,?352? ??1684?,?30?? ??800??,?36?
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?.????????
?????????? ??????????? ????
????????????? (toxicogenomics or
environmental genomics ) ?????????????(toxicoprot
eomics) ???????????(toxicometabonomics) ??????????
???????(in silico
toxicology)
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?.????????
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?????????????????????,???GLP?????GLP?????
??-??????????????????????????????,??????????????,?
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??? ??? ???? ??GLP??
?????(discovery toxicology) ????? (predictive
toxicology) ????? (In Silico toxicology) ??????
(QSAR)
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?.????????
??-???????????GLP?Guidline??,?????????????????????
??,??????????????????????????????
??-????????????????,??????????????(clinical
endpoint),????????????????????,????????????????
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Toxiblot??????????????????????????????????????????
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?? 4R ??,????? ?????????
???(alterative methods) in vitro and
computer technologies , use nonmammalian
rganisms, transgenic cell and animals
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?????? Toxicology ????????? Mutaion
Research ?????? Teratology ??????
Toxicological Science ?????? Experimental and
Human Toxicology
Toxicology Letter
Archives Toxicology Reproductive Toxicology
Mutagenesis Parmacology Applied
Toxicology Comparative Parmacology Toxicology
????????? ??.??.??? ???????????????????? ??
???????????????
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1.Casarett Doull Toxicology The Basic Science
of poison 1975??1? 2001??6? 2.Hayes
AW Principles Methods of Toxicology
1982?1? 2001?4? 3.Elseevier Science
Comprehensive Toxicology
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• ???,?????,???????,2007,9
• ???,?????,???????,2007,2