Tissue Engineering Initiative

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Tissue EngineeringInitiative

• Drexel University
• MCP Hahnemann University
• Philadelphia, PA

www.biomed.drexel.edu
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Tissue Engineering at Drexel/MCPHU
College of Engineering
College of Medicine
Biomedical Engineering
Center for Advanced Bio- Materials Tissue
Engineering
Center for Fibrous Materials Research
Implant Research Center
Nanotechnology Center
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Tissue Engineering at Drexel/MCPHU
Polymeric Scaffolds
Matrix Development
Cardiac Neuro Tissue Engineering
Cellular Molecular Biology
Replacement Organs
Comp. Tissue Engineering
Implant Research
mg Bioreactors
Nanofiber Composites
Stem Cell Research
Bone and Ligament Research
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Nanotechnology Center

• 10.5M Nanotechnology Center will
• Nucleate sustained regional growth
  innano-biotechnology
• Achieve national recognition in bio-nanoechnology

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Research Enterprise Building

• Research Enterprise Building Graduate
  Facilities
• 150,000 ft2 of Modern facilities (30M)
  theme-based laboratories including
• Nano Micro Technology
• Biosensors
• Tissue and Organ Engineering
• Neuro Engineering

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Tissue A group of similar cells united to perform
a specific function
Engineering The design and manufacture of
complex products through the application of
science and mathematics
Tissue Engineering
Scientific American 280(4) April 1999
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Tissue Engineering Matrix Development
Trabecular Bone Replacement
Cato Laurencin, PhD , M.D. Moorehead Chair
Professor Of Chemical Engineering and Biomedical
Engineering
Ligament Replacement
Nanotechnology
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Tissue Engineering of Bone Cellular and Animal
Studies
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Cellular Tissue Engineering
Cellular / Molecular Biology Development and
Differentiation
Peter I. Lelkes, PhD, Calhoun Chair Professor of
Cellular Tissue Engineering
Scaffolds / Nanotechnology

Stem Cells
Computer-Based Modeling
Bioreactor Biotechnology (NASA)
Functional Replacement Tissues
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Cellular Tissue EngineeringPrimary Target
Tissues/Organs

• Cardiovascular Tissues
• Blood Vessels
• Heart

• Neural Tissues
• Brain
• Peripheral Nerves

• Endocrine Tissues
• Pancreas
• Adrenal

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3-D Nanofiber Scaffold for Tissue Engineered
Cartilage
Frank Ko, Ph.D Professor of Materials Engineering
and Biomedical Engineering
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Vascular Tissue Engineering
Cell Mechanics Tissue Engineering
Kenneth A. Barbee, Ph.D Associate Professor of
Biomedical Engineering
Simulating the in vivo Mechanical Environment
to Promote the Development of Tissue Structure
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Atomic Force Microscopy for Measuring Mechanical
Properties of Cells in Engineered Constructs
Control of Smooth Muscle Injury During
Angioplasty to Prevent Restenosis
Mechanics of Neural Cell Injury and Acute Therapy
for Preservation of Neural Function
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Other Members of the Cellular Tissue Engineering
Team

• Fred Allen
• Assistant Professor of Biomedical Engineering
• Cell matrix interactions for orthopedic
  applications
• Cell motility and adhesion in tissue engineering

• Michele Marcolongo
• Associate Professor of Materials Engineering
• Orthopedic biomaterials and tissue engineering
  (Partners Rocky Tuan and Noreen Hickock,
  Orthopedic Surgery, Thomas Jefferson University)

• Wei Sun
• Assistant Professor of Mechanical Engineering
• Computational tissue engineering and modelling

• Margaret Wheatley
• Professor of Biomedical Engineering
• Responsive drug delivery for diabetes management
• Nanofiber mat (Partner Frank Ko)
• Spinal cord repair (Partners Itzhak Fisher and
  Marion Murray, Neurobiology, MCP Hahnemann
  University)

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Other Members of the Cellular Tissue Engineering
Team (Cont.)

• Yasha J. Kresh
• Professor and Research Director, Cardiothoracic
  Surgery and Cardiovascular Biophysics
  Computing, MCP Hahnemann Drexel University
• Complex cellular network dynamics (Partner Banu
  Onaral)
• Cardiac regenerative medicine

January 15, 2001
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School of Biomedical Engineering,Science
Health Systems
WWW.BIOMED.DREXEL.EDU

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