Smallpox Vaccine Adverse Events Public Health Guidance for Clinicians

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Eczema Vaccinatum
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Eczema Vaccinatum
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Eczema Vaccinatum
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Eczema Vaccinatum
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Progressive Vaccinia
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Progressive Vaccinia
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Enlarged Site vs PV Large Reaction Differentiation
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Enlarged Site vs PV Large Reaction Differentiation
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Progressive Vaccinia
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Post-Vaccinial EncephalitisDiagnosis

• Cerebral or cerebellar dysfunction
• Headache
• Fever
• Vomiting
• Altered mental status
• Lethargy
• Seizures
• Coma

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Post-Vaccinial EncephalitisDiagnosis

• Central nervous system lesions
• Cerebrum
• Medulla
• Spinal cord
• Lumbar Puncture
• Increased opening CSF
• Monocytosis
• Lymphocytosis
• Elevated CSF protein

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Post-Vaccinial Encephalopathy

• Infants under 2 years
• Acute onset 6-10 days post-vaccination
• Seizures
• Hemiplegia
• Aphasia
• Transient Amnesia
• Generalized cerebral edema
• Mild lymphocytic meningeal infiltration
• Widespread ganglion dengerative changes

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Post-Vaccinial Encephalomyelitis

• Older than 2 years
• 11-15 days after vaccination
• Fever
• Vomiting
• Headache
• Malaise
• Anorexia