Patrick M. Catalano, M.D., H. David McIntyre, M.D., J. Kennedy Cruickshank, M.D., David R. McCance, M.D., Alan R. Dyer, Ph.D., Boyd E. Metzger, M.D., Lynn P. Lowe, Ph.D., Elisabeth R. Trimble, M.D., Donald R. Coustan, M.D., David R. Hadden, M.D., Bengt

1
Patrick M. Catalano, M.D., H. David McIntyre,
M.D., J. Kennedy Cruickshank, M.D., David R.
McCance, M.D., Alan R. Dyer, Ph.D., Boyd E.
Metzger, M.D., Lynn P. Lowe, Ph.D., Elisabeth R.
Trimble, M.D., Donald R. Coustan, M.D., David R.
Hadden, M.D., Bengt Persson, M.D. Ph.D., Moshe
Hod, M.D., Jeremy J.N. Oats, M.D., For the Hapo
Study Cooperative Research Group
Diabetes Care Volume 35 780-786 April, 2012
2
Study Objective

• To determine associations of gestational diabetes
  mellitus (GDM) and obesity with adverse pregnancy
  outcomes in the Hyperglycemia and Adverse
  Pregnancy Outcome (HAPO) Study

Catalano P et al. Diabetes Care 201235780-786
3
Study Design

• Participants underwent a 75-g OGTT between 24 and
  32 weeks
•  
• GDM diagnosed post hoc using IADPSG criteria
•  
• Neonatal anthropometrics and cord serum C-peptide
  were measured
•  
• Adverse pregnancy outcomes included birth weight,
  newborn percent body fat, and cord C-peptide
  gt90th percentiles, primary cesarean delivery,
  preeclampsia, and shoulder dystocia/birth injury
•  
• Multiple logistic regression used to examine
  associations of GDM and obesity with outcomes

Catalano P et al. Diabetes Care 201235780-786
4
Catalano P et al. Diabetes Care 201235780-786
5
Catalano P et al. Diabetes Care 201235780-786
6
Catalano P et al. Diabetes Care 201235780-786
7
Conclusions

•  
• Both maternal GDM and obesity are independently
  associated with adverse pregnancy outcomes
•  
• Their combination has a greater impact than
  either one alone

Catalano P et al. Diabetes Care 201235780-786