NATIONAL ANIMAL GENOME RESEARCH PROJECT

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NATIONAL ANIMAL GENOME RESEARCH PROJECT

• NRSP-8

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NRSP-8

• Initiated October, 1993
• Revised October, 1998
• Termination
• (scheduled) October, 2003
• Revision in progress

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NRSP-8

• Participants in current project
• SAES 21 States
• USDA/ARS Four Locations
• Non-AES Universities Four
• Commodity Assn Three
• Private Industry Five
• Foreign Countries Three

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NRSP-8

• Administrative Advisors
• North Central Margaret Dentine--Lead
• South Jerry Cherry
• North East Bill Trumble
• West Colin Kaltenbach
• CSREES Richard Frahm

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NRSP-8

• OBJECTIVES
• 1. Develop high resolution comparative genome
  maps across species that link agricultural animal
  maps to those of the human and mouse genome

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NRSP-8

• OBJECTIVES
• 2. Increase the marker density of existing
  linkage maps used in QTL mapping and integrate
  them with physical maps of animal chromosomes

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NRSP-8

• OBJECTIVES
• 3. Expand and enhance internationally shared
  species genome databases and provide other common
  resources that facilitate genome mapping

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NRSP-8

• FY 2002 Budget
• MRF Funding 380,000
• Matching/Cost Sharing 456,000
• Total 836,000

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NRSP-8

• Species coordinators
• Selected by competitive process
• Administer database management and provide
  centralized resources
• Present annual reports to researchers
• Respond to questions and requests at annual
  meeting during technical committee meetings
• Coordinate with international efforts

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NRSP-8

• Commodity Budget
• Coordinators Allocation
• Cattle (TX) 60,000
• Swine (IA) 60,000
• Poultry (MI) 50,000
• Sheep (UT) 45,000
• Horses (KY) 45,000
• Databases ( IA, TX) 120,000

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NRSP-8

• Meetings/Communications
• Annual meeting in conjunction with Plant and
  Animal Genome Conference
• Coordinators communicate with participants via
  e-mail and web sitesdata submitted to
  international databases

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NRSP-8

• Annual Publications (3 yr. avg)
• Refereed Journal Articles 127
• Other Publications 136

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NRSP-8

• Brief Summary of Accomplishments
• Cattle Three major linkage maps with gt3000 loci
  now publishedCoordinator provides bovine
  reference DNA, fluorescent tagged and CATS
  primers and hybrid somatic cells to multiple
  laboratories

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NRSP-8

• Brief Summary of Accomplishments
• SheepDatabase containing physical and linkage
  maps published and available--gt450 microsatellite
  primer pairs mapped to ovine chromosomes have
  been distributed to more than 45 laboratories,
  worldwide for projects investigating wool traits,
  carcass composition, parasite resistance, growth
  characteristics, single gene defects, etc

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NRSP-8

• Brief Summary of Accomplishments
• Swine Over 650 genes and 1480 markers in swine
  database. Searchable swine EST database on line.
  Fluorescent primers prepared and shared with more
  than 40 laboratories world-wide53 issues of Pig
  Genome Update have been published and shared
  widely

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NRSP-8

• Brief Summary of Accomplishments
• PoultryHigh resolution poultry genome consensus
  maps have been published with more than 20,000
  markers. Large BAC libraries have been developed
  and a searchable genome mapping data base has
  been developed and is available on line

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NRSP-8

• Brief Summary of Accomplishments
• Equine Synteny, BAC and radiation hybrid panels
  have all been developed and are available for
  distributionan active web site has been
  established to publicize and share information on
  horse genome mapping

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NRSP-8

• Brief Summary of Accomplishments
• ANGENMAP website with public access
• http//www.genome.iastate.edu
• Has a discussion group (electronic list-serve)
  with 465 members worldwide.
• 1.4 million hits in 2001
• Tutorials, access to all animal databases,
  reviews of software, searchable gene maps

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NRSP-8

• IMPACTS
• Use of marker-assisted selection by genetic
  industry and private breeders initiated in most
  species

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NRSP-8

• IMPACTS
• Identification of specific genes having a major
  impact on growth, carcass merit, reproductive
  efficiency and health will lead to improved
  production traits of all species at reduced costs
  allowing more competitiveness on the world market

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NRSP-8

• Conclusions
• Use of these central resources provided by NRSP-8
  has allowed many institutions to participate in
  genetic mapping effort for livestock improvement
• Feedback from users is built into the system of
  support for research
• Modest investment for widespread payoffs

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NRSP-8

• Rationale for Off-The-Top Funding
• ? Animal genomics is a high priority
• ? Funding is very limited
• ? Central resources provide efficiencies of scale
  and leverage for national effort

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NRSP-8

• Rationale for Off-The-Top Funding-Cont
• ? Databases, primers and other materials would
  not have been available or available only in
  limited quantities were it not for NRSP-8
• ? Most Agricultural Experiment Stations have
  benefited directly from the materials or
  information provided by NRSP-8