2 SHM in human MZ B cells and in some mouse strains that can not generate GC'

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1) SHM in mouse GC B cells (GL-7intB220lo) that
showed little evidence of Ag selection
2) SHM in human MZ B cells and in some mouse
strains that can not generate GC.
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3) A single developmental program for B-cell
diversity in all advanced vertebrate species?
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(No Transcript)
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Developing B cells are more exposed to
IL-1R/TLR-ligands during peripheral development.
Does this exposure increase AICD levels, broaden
expression patterns, and/or promote SHM?
naïve, central
large pre-B
immature B
T1 B
AICD
time
pro-B
pre-proB
4) Can early expression of AID, e.g., in pro- and
pre-B cells influence the Ab repertoire?
inflamed, peripheral
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Does granulocytosis promote the
development/survival of the peripheral T1
compartment? Does this pathway to Ab production
carry a higher risk of autoAb?
Reactive granulocytosis increases BAFF levels at
sites of inflammation
Direct microbicidal activity
BAFF supports T1 cell differentiation to Ab
production
B-cell progenitors begin peripheral lymphopoiesis
Ti Ab response utilizes AICD-modified Ig that
binds microbes
Lymphocyte mobilization
TLR-L/IL-1?/TNFa increases AID expresssion
TNFa and IL-1?
BM increases granulocyte production
infection elicits inflammation