Hierarchy

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Hierarchy
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Excellent review and cartoons of Drosophila
development
http//flymove.uni-muenster.de/
Movies of Drosophila embryonicdevelopment
http//fly.ebi.ac.uk7081/images/lk/Animation/
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Localized bcd mRNA serves as a source for a
gradient of BCD in the embryo
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Evidence of importance of bcd
Anterior (head)
Wild type
bcd
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Bicoid Protein represses caudal mRNA translation
Caudal
Bicoid
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Hunchback promoter
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Hunchback promoter
hb
Bcd protein
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Hunchback Kruppel
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Gap gene interactionshttp//www.csa.ru/Inst/gorb_
dep/inbios/genet/s8gpnt.htm
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Pair-rule fushi tarazu (ftz)
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Even-skipped eve
eve
Kr
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Stage 14 - 20 minutes
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hunchback eve
Eve stripe 2 ACTIVATED by hb. Stripe 3
repressed
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How to make a stripe?
2
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hunchback eve
Eve stripe 2 ACTIVATED by hb. Stripe 3
repressed
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Kruppel eve
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Giant eve Kruppel
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Hunchback eve Kruppel
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Kruppel ftz
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Gene networks
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Even skipped Ftz
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Segement polarity - hedgehog
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Wild type
wg mutant
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http//www.stanford.edu/rnusse/pathways/
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References
Sanson (2001) EMBO Reports 2 1083-1088 C
Alexandre, M Lecourtois, and J Vincent
(1999) Development 126 5689-5698. Nusse
(2003) Development 130, 5297-5305