Case 1

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Case 1

• 8-month old child
• Diagnosis of acute lymphocytic leukemia
• Chemo-therapy/irradiation therapy
• Ascites, hepatosplenomegaly at 9 days post
  transplant
• Died at 24 days post transplant

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Trichrome Stain
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Case 1

• Diagnosis

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Case 2

• 52-year-old man
• Chronic liver disease, end stage
• Referred for transplant

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Iron Stain
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Case 2

• Diagnosis

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Case 3

• 33 year-old woman
• On steroids for SLE
• HBV
• End-stage liver failure
• At UCSF for liver transplant

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Trichrome Stain
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Trichrome Stain
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HBV Surface Ag
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HBV core Ag
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Case 3

• Diagnosis

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Case 4

• 58-year-old woman
• Chronic cholestasis
• Referred for liver transplantation

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Orcein Stain
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Case 4

• Diagnosis

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Case 5

• 55-year-old woman
• Chronic liver disease
• Referred for transplantation

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Trichrome Stain
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Trichrome Stain
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Case 5

• Diagnosis

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Case 6

• 67-year-old woman
• Adult onset diabetes
• Mildly obese
• ALKP 131 (nl 36-122)
• AST 50 (nl 12-42)
• History of 2 colon cancers, 1 breast cancer, on
  tamoxifen

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Trichrome Stain
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Trichrome Stain
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Case 6

• Diagnosis

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Case 7

• 19-year-old woman
• Fulminant liver failure
• 2 wks prior vomiting, fatigue
• Negative screens for viral hepatitis
• Sepsis, death

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Trichrome Stain
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Reticulin Stain
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Copper Stain- Rubeanic Acid
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Case 7
Test Liver Copper Serum Copper Ceruloplasmin Value 711 mg/g 394 mg/dl 11 mg/dl Normal (10-15) (75-150) (18-45)
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Case 7

• Diagnosis

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Case 8

• 80-year-old man
• Prostate adenocarcinoma
• Therapy with flutamide

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Reticulin Stain
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Trichrome Stain
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Case 8

• Diagnosis