Title: CARDS: The Collaborative Atorvastatin Diabetes Study
1 CARDS The Collaborative Atorvastatin Diabetes Study
To assess the effectiveness of 10 mg atorvastatin daily in the primary prevention of cardiovascular disease in patients with type 2 diabetes but without high concentrations of LDL-cholesterol
Colhoun HM Betteridge PN Hitman GA et al. Primary prevention of cardiovascular disease with atorvastatin in the Collaborative Atorvastatin Diabetes Study (CARDS) multicentre randomised placebo-controlled trial. Lancet 2004264685696.
2 CARDS The Collaborative Atorvastatin Diabetes Study - TRIAL DESIGN -
Multicenter multinational randomized double-blind parallel group
2838 patients aged 40-75 yrs with type 2 diabetes mellitus and at least one of hypertension retinopathy albuminuria smoking. Patients with history of MI angina coronary vascular surgery cerebrovascular accident or severe peripheral vascular disease ineligible
Follow up and primary endpoint
Primary endpoint acute coronary event coronary revascularization or stroke. Median 3.9 years follow-up
Atorvastatin 10 mg per day or placebo
3 CARDS The Collaborative Atorvastatin Diabetes Study - TRIAL DESIGN continued- Baseline characteristics 4 CARDS The Collaborative Atorvastatin Diabetes Study - RESULTS -
Compared with placebo patients receiving 10 mg atorvastatin daily showed a 37 reduction in major cardiovascular events from 9.0 to 5.8 (p 0.001)
There was a favourable trend in the atorvastatin group with regard to all cause mortality acute coronary events coronary revascularization and stroke
Adverse event rate similar in atorvastatin and placebo groups.
No cases of rhabdomyolysis.
5 CARDS The Collaborative Atorvastatin Diabetes Study - RESULTS continued -
6 CARDS The Collaborative Atorvastatin Diabetes Study - RESULTS continued - Breakdown of primary endpoint by treatment 7 CARDS The Collaborative Atorvastatin Diabetes Study - RESULTS continued - 8 CARDS The Collaborative Atorvastatin Diabetes Study - SUMMARY -
Atorvastatin (10 mg once daily) is safe and effective in reducing the risk of cardiovascular events including stroke in patients with type 2 diabetes
There was a favourable trend in the atorvastatin group with regard to all cause mortality major coronary events coronary revascularization and stroke
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