Title: Nutrition%20526%20-%209/29/2006%20A%20Public%20Health%20Approach%20to%20Maternal%20and%20Infant%20Health
1Nutrition 526 - 9/29/2006A Public Health
Approach to Maternal and Infant Health
2Topics
- Who is having babies in the US? How many babies?
What are the outcomes? - Why is nutrition important for pregnant women and
babies? - What population based approaches to improve
nutrition might improve outcomes?
3Topic 1
- How many babies?
- Who is having babies in the US?
- Race/ethnicity
- Age
- Marital status
- What are the nutrition-related outcomes we are
concerned about for population health?
4Health, United States, 2005 www.cdc.gov/nchs/hus
.htm
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14Percentage of Parents Who Were Married or
Cohabiting at Birth of First Child, by
Race/Ethnicity and Sex
MMWR September 15, 2006 / 55(36)998
15Infant Mortality
- Infant mortality rate Deaths of infants aged
under 1 year per 1,000 or 100,000 live births.
The infant mortality rate is the sum of the
neonatal and postneonatal mortality rates. - Neonatal mortality rate Deaths of infants aged
0-27 days per 1,000 live births. The neonatal
mortality rate is the sum of the early neonatal
and late neonatal mortality rates - Postneonatal mortality rate Deaths to infants
aged 28 days-1 year per 1,000 live births.
16http//www.chipublib.org/004chicago/disasters/infa
nt_mortality.html
17Infant Deaths Per Thousand Live Births, by Race
and Hispanic Origin 1960-1995
National Center for Health Statistics. Health,
United States, 1995
18Racial/Ethnic Disparities in Infant Mortality ---
United States, 1995--2002
MMWR June 10, 2005 / 54(22)553-556
19MMWR, April 19, 2002 / 51(15)329-332, 343
20Figure 2. Rates of infant mortality, low
birthweight, and preterm birth, 1990-2002
Supplemental Analyses of Recent Trends in Infant
Mortality, CDC February 11, 2004
21Health Affairs, Vol 23, Issue 5, 2004
22Causes of Infant Death
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24Health Affairs, Vol 23, Issue 5, 2004
25Rates of LBW () Rates of Premature Birth () Rates Infant Morality()
African Americans 13.4 17.7 13.5
Asians 7.8 10.4 4.6
Native Americans 7.2 13 9.7
Whites 6.9 11 5.7
Hispanics 6.5 11.6 5.4
NGA Center for Best Practices, June 2004
26 Reported Stressful Life Events During Year
Before DeliveryKing County, 1999-2001Pregnancy
Risk Assessment Monitoring System (PRAMS)
27African Amer. Amer. Indian/AK Native White
Changed residence 44 53 33
Argued with partner more than usual 36 43 17
Had bills couldnt pay 31 42 14
Someone close died 24 25 15
Close family member hospitalized 24 22 24
Separated or divorced from partner 20 19 5
Someone close had drinking/drug problem 15 28 13
Partner said he didnt want pregnancy 15 21 8
Husband/partner lost job 14 20 8
Mom or partner went to jail 10 22 4
Involved in a physical fight 7 12 4
Homeless 11 15 1
Reported 5 or more stress events 12 23 4
stat. sig compared to whites
28Maternal Mortality
29African American and White Women Who Died of
Pregnancy Complications, United States
Annual number of deaths during pregnancy or
within 42 days after delivery, per 100,000 live
births. The apparent increase in the number of
maternal deaths between 1998 and 1999 is the
result of changes in how maternal deaths are
classified and coded. Source CDC, National
Center for Health Statistics.
30Risk of Maternal Death
- Race/ethnicity
- The risk of death for African American women is
almost four times that for white women. - The risk of death for Asian and Pacific Islander
women who immigrated to the United States is two
times that for Asian and Pacific Islander women
born in the United States. - Age
- The risk of death is nearly three times greater
for women 3539 years old than for women 2024
years old. - The risk is five times greater for women over 40.
31The most common serious pregnancy complications
- Ectopic pregnancy
- Depression
- High blood pressure
- Infection
- Complicated delivery
- Diabetes
- Premature labor
- Hemorrhage
32Topic 2
- Why is nutrition important for pregnant women and
babies?
33Poor Pregnancy Outcomes are Costly
- Medicaid finances 40 of annual births in the US
and pays for 50 of hospital stays for premature
and LBW. - The care cost for children with one of 17 common
birth defects is 8 billion per year in the US.
34Top Three Best Practices to Improve Birth
Outcomes and Reduce High Risk Births (NGA, June
2004)
- Improve access to medical care and health care
services - Encourage good nutrition and healthy lifestyles
- Eating healthy foods
- Taking folic acid
- Reduce use of harmful substances
35Emerging Understandings about Nutrition in
Pregnancy
- Fetal nutritional status is affected by the
intrauterine and childhood nutritional
experiences of the mother - Maternal nutritional status at time of conception
is an important determinant of outcomes - Intrauterine nutritional environment affects
health and development of the fetus throughout
life
36Emerging Understandings about Nutrition in
Pregnancy
- Periods of critical development are key when
considering effects of nutrition in pregnancy. - Undernutrition has different effects at different
times of life. - Societies transitioning from chronic malnutrition
to access to high calorie foods are at high risk
of chronic disease due to lasting effects of
early nutritional status.
37Effect of Womens own Intrauterine Nutritional
Experience her Offspring
38Two Studies of Effects of Maternal Birthweight on
Infant Birthweight
39Classic Definitions of Birth weight
Extremely low birth weight (ELBW) lt 1000 g
Very low birth weight (VLBW) lt1500 g
Moderately Low birth weight 1500 to lt2500 g
Low birth weight lt2500 g (HP2010)
Normal (NBW) 2500-lt4000 g
Ideal birth weight 3500- lt4000g
High birth weight (HBW) gt4000 g
40Godfrey KM, Barker DJP, Robinson S, Osmond C.
Mother's birthweight and diet in pregnancy in
relation to the baby's thinness at birth. Br J
Obstet Gynaecol 19971046637
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42Illinois StudyCoutinho et al. Am J Epi, 1997
146804-809
- N15,287 Black and 117,708 white matched pairs of
infants and mothers. - Mothers were born between 1956-75, infants
between 1989-1991
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44Results
- Fathers birthweight had effect on infant
birthweight but not as strong as mothers. - In multiple linear regression for infants who
weighed more than 2500 g, parental birthweight
accounted for 5 of variance among black infants
and 4 among white infants. - (adjusted for parental age, years of schooling,
marital status and adequacy of prenatal care)
45Results, cont.
- Each 100 g increase in maternal birthweight was
associated with 24-27 g increase in infant
birthweight
46Influence of Maternal Intrauterine Childhood
Nutrition on Outcomes of Pregnancy
47Reproductive performance and nutrition during
childhood
- Nutrition Reviews Washington Apr 1996
Martorell, Reynaldo Ramakrishnan, Usha
Schroeder, Dirk G Ruel, Marie
48Longitudinal Supplementation Trial (1969-1977)
- Guatemala, 4 Villages, one pair of villages had
about 900 people each and the other about 500
each. - 2 each randomized to
- Atole (Incaparina, a vegetable protein mix
developed by INCAP, dry skim milk, sugar, and
flavoring, 163 kcal/cup, 11/5 g protein) - Fresco (flavored drink with sugar, vitamins and
minerals, 59 kcal/cup)
Institute of Nutrition of Central America and
Panama
49- Feeding center was open daily for over 7 years,
from 1969 to 1977. - Anyone in the village could attend, but careful
recording of consumption, including of additional
servings as well as of leftovers, was done only
for women who were pregnant or breastfeeding and
for children 7 years or younger. - Supplements were available twice daily, in
midmorning and midafternoon, so as not to
interfere with meal times.
50Conceptual framework
- Malnutrition in early childhood constrains the
future capacity of women to bear healthy newborns
and their ability to feed and care for them, and
through these mechanisms the growth and
development of the next generation.
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56Follow-Up data - 1990s
- The prevalence of low birthweight is currently
12 in Atole villages (n 65) and 28 in Fresco
villages (n 58) among women exposed to the
supplements during the intrauterine period and
the first 3 years of life. - Mean birthweights are 2.90 kg in Atole villages
and 2.73 in Fresco villages.
57Role of intergenerational effects on linear
growth
- U Ramakrishnan R Martorell D G
- Schroeder R Flores The Journal of Nutrition
Bethesda Feb 1999
58Methods
- The sample was restricted to singleton, term (gt37
wk of gestation) births that occurred in the four
study villages between 1991 and 1996, to women
who were born during the original longitudinal
study (1969-1977) - Complete data were available for 215 mother-child
pairs, and 60 of the mothers (n 140)
59Results
- For every 100 g increase in maternal birth
weight, her infant's birth weight increased by 29
g after adjusting for the effects of maternal
age, gestational age and sex of the infant. This
relationship was highly significant (P lt 0.001) - For every centimeter increase in maternal birth
length, her child's birth weight increased by 53
g.
60Influence of Maternal Nutrition in Pregnancy
61Dutch Famine StudiesSusser and Stein, Nutrition
Reviews, 1994
- Dutch famine winter lasted 6 months, from
November 1944- when nazis imposed transport
embargo on west Holland until- - May 7, 1945 when Holland was liberated from the
occupation - Strong evidence for critical stages of
development in several physiological systems
62Affects of Famine
- Fertility decreased
- Maternal weight fell during pregnancy with famine
exposure - Third trimester famine exposure had strong effect
on birthweight - Third trimester famine exposure was associated
with infant mortality at 30-90 days
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64Results for Infants Exposed to Famine
- Excess central nervous system disorders (such as
NTD) - Exposure early in gestation associated with
excess obesity in young men (military records)
and women - Famine exposure late in pregancy associated with
less obesity in young adulthood - Famine exposure associated with twofold risk of
schizophrenia in 50 year old women.
65Second Generation
- Modest association found in this cohort between
birthweights of mothers and their offspring.
66Prenatal exposure to famine and brain morphology
in schizophrenia
- Hulshoff Pol HE Hoek HW Susser E Brown AS
Dingemans A Schnack HG van Haren NE Pereira
Ramos LM Gispen-de Wied CC Kahn RS American
Journal of Psychiatry , Jul 2000
67Methods
- Nine schizophrenic patients and nine healthy
comparison subjects exposed during the first
trimester of gestation to the Dutch Hunger Winter
were evaluated with magnetic resonance brain
imaging, as were nine schizophrenic patients and
nine healthy subjects who were not prenatally
exposed to the famine.
68RESULTS
- Prenatal famine exposure in patients with
schizophrenia was associated with decreased
intracranial volume. - Prenatal Hunger Winter exposure alone was related
to an increase in brain abnormalities,
predominantly white matter hyperintensities.
69Further evidence of relation between prenatal
famine and major affective disorder.
- Alan S Brown Jim van Os Corine Driessens Hans
W Hoek et al The American Journal of
Psychiatry Washington Feb 2000
70Methods
- Compared the risk of major affective disorder
requiring hospitalization in birth cohorts who
were and were not exposed, in each trimester of
gestation, to famine during the Dutch Hunger
Winter of 1944-1945.
71Results
- The risk of developing major affective disorder
requiring hospitalization was increased for
subjects with exposure to famine in the second
trimester and was increased significantly for
subjects with exposure in the third trimester,
relative to unexposed subjects.
72Fetal Nutrition and Chronic Diseases of Adulthood
73Fetal Origins ConceptsBarker et al
- Nutrition in early life has permanent effects on
structure, physiology and metabolism - Undernutrition has different effects at different
times of life (critical periods of development) - Rapidly growing fetuses and neonates are
vulnerable to undernutrition - Undernutrition results from inadequate maternal
intake, transport, or transfer of nutrients.
74Coronary heart disease death rates, expressed as
standardized mortality ratios, in 10,141 men and
5585 women born in Hertfordshire, United Kingdom,
from 1911 to 1930, according to birth weight.
(Osmond C, Barker DJP, Winter PD, Fall CHD,
Simmonds SJ. Early growth and death from
cardiovascular disease in women. BMJ
1993307151924)
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76Catch-up growth in childhood and death from
coronary heart disease longitudinal study
(Eriksson et al, BMJ, 1999)
- Subjects 3641 men born in Helsinki between
1924-1933 - Followed with school data for weight and height
- Deaths from coronary heart disease from 1971-95
(standardized mortality ratios) were endpoints.
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78Catch-up growth in childhood and death from
coronary heart disease longitudinalstudy
(Eriksson et al, BMJ, 1999
- Men who had low birth weight or were thin at
birth have high death rates from coronary heart
disease - Death rates are even higher if weight "catches
up" in early childhood - Death from coronary heart disease may be a
consequence of prenatal undernutrition followed
by improved postnatal nutrition - Programs to reduce obesity among boys may need to
focus on those who had low birth weight or who
were thin at birth
79Framework for understanding the maternal
regulation of fetal development and programming.
Keith M Godfrey and David JP Barker (Fetal
nutrition and adult disease Am J Clin Nutr 2000
71 1344-1352)
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81Early Nutrition Chronic Disease in Adulthood
(Waterland Garza, Am J Clin Nutr, 199969179-97)
- Epi studies BMI, CVD, Htn, IGT
- Animal studies
- Potential mechanisms of metabolic imprinting
82Obesity in Young Men after Famine Exposure in
Utero and early Infancy(Ravelli et al NEJM, 1976)
- N300, 000 Dutch military inductees at age 19
- Famine exposure in first 2 trimesters lead to 80
higher prevalence of overweight (plt0.0005) - Famine exposure in last trimester or famine
exposure in first 5 months of life associated
with 40 lower prevalence of overweight (plt0.005)
83BMI
- The relationship between birth weight and BMI
complicates studies of birth weight and chronic
disease
84Preadult Influences on Cardiovascular Disease and
Cancer (Leon Ben-Shlomo in A Lifecourse
approach to chronic disease epidemiology, 1997)
- 5 large retrospective studies - 4 found inverse
relationship between birth weight and adult CVD - Confounding issues include SES and BMI
85CVD
- The preponderance of data suggest an inverse
association between birth weight and adult CVD
risk. (Waterland and Garza)
86Blood Pressure
- Retrospective studies in diverse populations
have found that birth weight is inversely
correlated with adult blood pressure. Although
each of the studies has some weaknesses, together
they support a biological link between
intrauterine growth and adult blood pressure
(Waterland and Garza)
87Impaired Glucose Tolerance
- Several large retrospective cohort studies in
several countries have found relationship between
bw and IGT. - 266 men and women at age 50 odds ratio for ITG
or type II diabetes were 3.5 for men and 12 for
women with birth weights lt 2.5 compared to gt3.4
(Phillips et al, Diabetologia, 1994)
88Impaired Glucose Tolerance, cont..
- In some populations (ex Pima Indians) both high
and low birth weights are associated with IGT in
adults.
89Animal Models (Waterland and Garza)
- Overall the data from animal models of metabolic
imprinting support the observed epidemiological
associations.
90Epigenetics
- Epigenetics the study of stable alterations in
gene expression that arise during development and
cell proliferation Epigenetic phenomena do NOT
change the actual, primary genetic sequence - Epigenetic phenomena are important because,
together with promotor sequences and
transcription factors, they modulate when and at
what level genes are expressed - The protein context of a cell can be understood
as an epigenetic phenomena. - Examples include DNA methylation, histone
hypo-acetylation, chromatin modifications,
X-inactivation, and imprinting.
http//cnx.rice.edu/content/m11532/latest/
91Metabolic Imprinting
- the basic biological phenomena that putatively
underlie relations among nutritional experiences
of early life and later diseases.
92Metabolic Imprinting Characteristics
- Susceptibility limited to a critical ontogenic
window early in development - Persistent effect lasting through adulthood
- Specific and measurable outcome
- Dose-response or threshold relation between
exposure and outcome
93Metabolic Imprinting Potential Mechanisms
- Organ structure
- Cell number function
- Clonal selection
- Metabolic differentiation
94Organ Structure
- Organogenesis starts early by 5 weeks
rudimentary organs are in place, by 8 weeks
organogenesis is nearly complete - Driven by inductive signals from adjacent cells
and morphogen gradients (ex retinoic acid/vit.
A) - Local concentrations of nutrients and metabolites
may modulate this process.
95Cell Number
- Tissues go through limited periods of
hyperplastic and hypertrophic growth - Rate of growth is dependent on nutrient
availability - Winnicks rat studies found severe malnutrition
during critical periods limited brain cell number
- An organs metabolic activity is limited by cell
number
96Cell Function
- Early nutrition may influence the cascade that
establishes cell specific patterns. - Ex hepatocyte polyploidization - in adults
hepatocytes often have gt normal complement of
chromosomes and increased metabolic activity.
Lack of polyploidization could limit hepatic
metabolic activity.
97Clonal Selection
- Each organ is based on a finite number of founder
cells which may have slight differences - Founder cells that divide the most rapidly may
disproportionally make up a tissue - Nutrient availability may select cells with
certain characteristics - Ex cells with more active lipogenic pathways
could grow faster if access to fatty acids was
limited
98Metabolic Differentiation
- Process cells develop stable patterns of basal
and inducible gene expression - Cells are characterized by the ability to express
a limited number of genes. - Mechanisms of control include
- chromatin structure (DNA packaging)
- transcription factors (maintained through cell
divisions) - DNA methylation
99Fall et al, 1988
100Gluckman et al. Biology of the Neonate, 2005
101Topic 3
- Public Health Approaches to Nutrition and
Pregnancy - Assessment
- Policy Development
- Assurance
102Assessment
- Planning for Pregnancy
- Risk Behaviors
103Effects of pregnancy planning status on birth
outcomes and infant care (Kost et al. Family
Planning Perspectives, 1998)
- Analysis of 1988 NMIHS (n9122) and NSFG (n2548)
data.
104Effects of pregnancy planning status on birth
outcomes and infant care (Kost et al. Family
Planning Perspectives, 1998)
105Effects of pregnancy planning status on birth
outcomes and infant care (Kost et al. Family
Planning Perspectives, 1998)
- Knowing the planning status of a pregnancy can
help identify women who may need support to
engage in prenatal behaviors that are associated
with healthy outcomes and appropriate infant
care.
106Surveillance for Pregnancy
- PRAMS results Washington State
107Alcohol
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109MMWR, December 24, 2004
110Multivitamin Use
111Multivitamin Use
112Breastfeeding Duration
113Breastfeeding Duration
114Smoking
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118Unintended Pregnancy
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120Post-Partum Depression PRAMS
121Washington State PRAMS
122WA State PRAMS
123Key Indicators of Perinatal Health for Washington
Residents August 2005
- The total number of live births has remained
stable since 1998 at approximately 80,000 births
per year. - Medicaid-funded deliveries represented 45.6 of
births in 2003. - Birth rates and pregnancy rates decreased among
teens 15-17 years and 18-19 years, especially
from 1993 to 2003. - Since the mid-1990s, total infant mortality,
race-specific infant mortality and
Medicaid-specific infant mortality have decreased
slightly.
124Indicators, cont.
- SIDS rates have decreased substantially since
1990, however changing reporting practices of
coroners/medical examiners have played a role in
this decline. - Smoking during pregnancy, as reported on the
birth certificate, has declined since 1992. - In 2002, the percent of women initiating
breastfeeding was high in Washington State at
approximately 90.
125Areas of Concern in WA State
- Total low birth weight has increased steadily
since 1990, in part due to the increase in
multiple deliveries. - In 2003, African American and Native American
infant mortality rates continued to exceed infant
mortality rates of other race and ethnic groups. - In 2003, the highest singleton low birth weight
(LBW) rate was for African Americans.
Key Indicators of Perinatal Health for Washington
Residents August 2005
126Concerns, cont.
- The singleton VLBW rate among African Americans
remained over twice the rate of Whites between
1990 and 2003. - In 2003, women receiving Medicaid had lower rates
of first trimester prenatal care and higher rates
of late and no prenatal care than women who did
not receive Medicaid. - In 2003, smoking rates during pregnancy were
significantly higher for women receiving Medicaid
than for women who did not receive Medicaid. - In 2002, the unintended pregnancy rate was
approximately 54.
127Healthy People 2010 Goals Related to Maternal and
Infant Nutrition
128Reduce low birth weight (LBW) and very low birth
weight (VLBW).
129Reduce preterm births
130Reduce the occurrence of spina bifida and other
neural tube defects (NTDs)
- Target 3 new cases per 10,000 live births.
- Baseline 6 new cases of spina bifida or another
NTD per 10,000 live births in 1996.
131Increase the proportion of pregnancies begun with
an optimum folic acid level.
132Increase abstinence from alcohol, cigarettes, and
illicit drugs among pregnant women
133Increase the proportion of mothers who breastfeed
their babies
134Increase smoking cessation during pregnancy
- Target 30 percent.
- Baseline 12 percent smoking cessation during the
first trimester of pregnancy in 1991 (age
adjusted to the year 2000 standard population).
135Reduce growth retardation among low income
children under age 5 years
- Target 5 percent.
- Baseline 8 percent of low-income children under
age 5 years were growth retarded in 1997 (defined
as height-for-age below the fifth percentile in
the age-gender appropriate population using the
1977 NCHS/CDC growth charts31 preliminary data
not age adjusted).
136Reduce iron deficiency among young children and
females of childbearing age.
137Reduce anemia among low-income pregnant females
in their third trimester
- Target 20 percent.
- Baseline 29 percent of low-income pregnant
females in their third trimester were anemic
(defined as hemoglobin lt 11.0 g/dL) in 1996
138Anemia Rates - 1996
- African American, non-Hispanic 44
- American Indian/Alaska Native 31
- Asian/Pacific Islander 26
- Hispanic 25
- White, non-Hispanic 24