Ongoing Competitive Clinical Trials Information

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• Ongoing Competitive Clinical Trials Information
• Mining for Gold
• Zorba B. Lieberman
• June 6, 2005

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What is TrialTrove?
Competitive Clinical Trials Surveillance Service

• Global coverage of ongoing trials
• Customized Web-enabled database shared across the
  enterprise
• Continuously up to date
• Mechanism to include internal intelligence
• Built-in alerting system
• Unlimited research support

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Themes for Today

• Getting the information
• Where ongoing trials information can be found and
  how much is out there
• Using the information
• Understand where your competitor is with
  executing on their strategy
• Making adjustments to your own drug development
  and commercialization strategy

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Trials Information Sources

• Web sources including
• Government (clinicaltrials.gov, cancer.gov)
• Other trials listings sources (controlled trials
  UK, Centerwatch)
• Research centers community hospitals
• Company Web sites
• News feeds
• SEC filings and analyst conference calls
• Medical meetings

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Example Breast Cancer Trials
diagnostic, genetic marker, non-Rx treatment
trials excluded.
Source Citeline, clinicaltrials.gov
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Example Breast Cancer Trials
1,092 Trials (2.3x)
Ex-US
431 (5.1x)
US
473 Trials
85
Ex-US
661 (1.7x)
US
388
clinicaltrials.gov
TrialTrove
Source Citeline, clinicaltrials.gov
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How Clients Use Trials Information
to understand their competitive environment
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Targeted Indications Bay 43-9006
Number of Trials
Targeted Cancer Type
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Bay 43-9006 trials in 23 countries
1
10
3
22
23
1
2
1
1
3
2
1
10
Bay-43-9006 Clinical Development Program
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The Value of Trials Information for CI

• Discovery
• I didnt know that Company X had initiated a
  Phase II trial in Glioblastoma..!
• Get depth of detail
• Details of trial design offer leading edge
  insights into competitor plans
• Identify patterns
• Asses a competitors commercialization strategy

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How Clients Use Trials Information
to adjust their own development programs as the
competitive environment changes
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Phase II and III Anti-VEGF Trials
Number of Trials
Targeted Cancer Type
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Historical Enrollment Rates
Source Citeline (sample of
Alzheimers trials data)
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Using Trials Information to Make Internal
Business Decisions

• Decide which indications to target
• Predict trial duration
• Assess protocol design
• Optimize geography to find patients
• Identify investigators/KOLs

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Summary

• There is a lot of ongoing trials information out
  there, but it is very fragmented and diffuse
• Effectively assimilating the fragments can offer
  a tremendous competitive advantage
• Besides understanding competitors actions and
  intent, companies can use this information to
  optimize their own drug development