Traditional Chinese Medicine and emerging technologies

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Traditional Chinese Medicine and emerging
technologies

• Peter Hylands Pharmaceutical Science Division,
  School of Biomedical Health Sciences, Kings
  College London
• Xu Qing Dalian Institute of Chemical Physics
• The Royal Society, 4 June 2007

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Background

• More than 3,000 Traditional Chinese medicine
  practitioners in the UK
• Materials imported in unprocessed form or as
  patent medicines
• Regulatory situation confused and variable
• Problems with substitution and adulteration as
  well as use in combination with western drugs
• China has highlighted TCM development as a
  priority

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Problems

• TCM almost never have one active ingredient and
  may work synergistically
• Conventional pharmaceutical analytical methods
  therefore not applicable
• Chromatographic fingerprinting initiative
  included in Chinese Pharmacopoeia

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Application of metabonomics

• To define quality and investigate mechanism of
  action
• Quality leading to standardisation as a
  prerequisite for clinical trials
• High field nuclear magnetic resonance
  spectroscopy
• Proteomics

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High field nuclear magnetic resonance spectroscopy
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Principal components analysis
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Proteomics
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Phytochemical informatics
nACh receptor GABA receptor Na K ATPase Voltage
dependent Na channel Alpha-1 adrenergic
receptor Dopamine receptor Acetylcholinesterase
Monoamine oxidase iNOS expression NO in vivo
cAMP dependent phosphodiesterase Calmodulin
dependent protein kinase MLCK Protein kinase
A Protein kinase C Topoisomerase II Apoptotic
HIV-1 reverse transcriptase HIV-1 protease HIV-1
integrase Testosterone 5 alpha
reductase Oestrogen receptor Aromatase Phospholipa
se Cycloxygenase Lipoxygenase Aldose reductase

• Ehrman, TM, Barlow, DJ and Hylands, PJ (2007)
• Virtual Screening of Chinese Herbs with Random
  Forest J Chemical Information Molecular
  Modelling 47 264-278

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Compounds ordered by TCM profile/usage

• Constituents of Herbs in the Invigorate Blood TCM
  Category
• For treating severe pain ulcer

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• Thank you for your attention
• peter.2.hylands_at_kcl.ac.uk