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Advanced Tissue Engineering Tissue Engineering III

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Objectives: To provide graduate and advanced (senior) undergraduate biomedical ... P. Lanza, Robert Langer, William L. Chick, Hardcover / January 1997 / 0124366252 ... – PowerPoint PPT presentation

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Title: Advanced Tissue Engineering Tissue Engineering III


1
Advanced Tissue Engineering Tissue Engineering
III
  • Spring 2005

2
Advanced Tissue Engineering III, Spring 2005
  • Objectives To provide graduate and advanced
    (senior) undergraduate biomedical
    engineering/science students with more detailede
    knowledge of (factor-mediated) tissue
    engineering
  • Course length 11 weeks
  • Prerequisite Courses TE I and TE II
  • Venue/Dates
  • New College Building 19th floor Conference Room
  • Wednesdays 1200 - 200

3
Advanced Tissue Engineering III, Spring 2005
  • Textbooks
  • No suitable text book available (yet). Will use
    select chapters from
  • Lanza et al. Principles of Tissue Engineering,
    2nd edition, Acad. Press, 2000
  • Lanza et al Principles of Tissue Engineering,
    1st edition, Acad. Press, 1997
  • Palsson and Bhatia Tissue Engineering, Pearson
    Prentice Hall, 2003
  • Saltzmann Tissue Engineering, Oxford University
    Press, 2004
  • Dee, Kay C., Puelo Avid A., and Bizios Rena An
    Introduction to Tissue-Biomaterials Interactions,
    Wiley Liss Hoboken, NY, 2002.
  • Elçin Y. Murat (ed) Tissue Engineering, Stem
    Cells, and Gene Therapies. Advances in
    Experimental Medicine and Biology vol 534. Kluwer
    Academic/ Plenum Press, New York, NY, 2003.

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Advanced Tissue Engineering III, Spring 2005
5
Tissue Engineering Engineering Principles for the
Design of Replacement Organs and Tissues W.
Mark Saltzman Oxford Universitry Press, July 2004
6
Advanced Tissue Engineering III, Spring 2005
  • Other Relevant Textbooks
  • Tozeren and Byers New Biology for Engineers
    Computer ScientistsPrentice Hall  2003 
  • Alberts et al., Molecular Biology of THE CELL 4th
    edition., Garland, 2002 ()
  • Lodish et al. Molecular Cell Biology, 4th
    edition, Freeman, 2000()
  • Gilbert Developmental Biology, 6th edition,
    Sinauer, 2000 ()
  • Karp Cell and Molecular Biology 2nd edition,
    Wiley 1999
  • Cooper Cell, a Molecular Approach, Sinauer ,
    1997
  • Alberts et al. Essential Cell Biology, Garland,
    1998
  • Pollack Cells, Gels and Engines of Life, Ebner
    and Sons, 2001
  • ()Avaiable on line http//www.ncbi.nlm.nih.gov/en
    trez/query.fcgi?dbBooks

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Advanced Tissue Engineering III, Spring 2005
  • Week 1 Introduction Tools of the Trade
  • Cells and their Interaction with their
    Environement (Factors)
  • Week 2 Cells, Scaffolds, Bioreactors
  • Week 3 Stem Cells and their Differentiation in
    vivo and in vitro
  • Week 4 Factors I Biochemical Factors
  • Week 5 Factors II Mechanical Factors
    I-Scaffolds
  • Week 6 Factors III Mechanical Factors
    II-Hemodynamic Factors
  • Mid-Term Examination Review Paper (2 weeks)
  • pilelkes_at_drexel.edu lelkes 123_at_AOL.COM

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Advanced Tissue Engineering III, Spring 2005
  • Week 7 Cardiovascular Tissue Engineering
    (Midterm due) Blood Vessels
  • Week 8 Cardiac Tissue Engineering Hearts and
    their Parts Models
  • Week 9 Skeletomuscular Tissue Engineering Bone,
    Cartilage and Tendon
  • Week 10 Tissue Engineering of Visceral Organs
    Liver, Pancreas
  • Week 11 Latest Developments in TE Stem Cell
    Therapy, Organ Printing, Ethics
  • Final Examination Research Proposal (5 weeks)

10
Advanced Tissue Engineering III, Spring 2005
  • Mid-Term (Review) Paper
  • Topics assigned 2 week before midterms , based
    on first 5 lectures Format J. Cell Biol
  • Undergraduate Students
  • (SENIORS)
  • 10 -12 pages, double spaced, 1 margins, 11 pt
    TNR, min 10 references
  • Graduate Students
  • 18 - 20 pages , double spaced, 1 margins, 11 pt
    TNR, min 20 references
  • Final Examination - Research Proposal
  • Topics will be assigned after midterm
  • Format NIH proposal
  • Undergraduate Students (SENIORS)
  • 18 - 20 pages, double spaced, 1 margins, 11 pt
    TNR min 15 references
  • Graduate Students
  • 30 - 35 pages, double spaced, 1 margins, 11 pt
    TNR min 30 references

11
Advanced Tissue Engineering III, Spring 2005
  • Peer Review System
  • Mid-Term
  • Papers due May 1, 2005
  • Reviews due May 6, 2005
  • 2. Finals
  • Papers due June 5, 2005
  • Reviews due June 10, 2005
  • Example for Peer-Review System
  • Authors Peer Reviewers
  • Paper/Proposal Midterm Final
  • 1 3 5
  • 2 4 6
  • 3 5 7
  • 4 6 1
  • 5 7 2
  • 6 1 3
  • 7 2 4

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Advanced Tissue Engineering III, Spring 2005
  • Grading
  • 10 Participation in Class
  • 20 Journal Club/Presentation
  • 30 Midterm Paper ( peer-review)
  • 40 Final Research Proposal ( peer-review)
  • Grades
  • A 100 - 95 outstanding
  • (extra effort, undergraduates at graduate level)
  • A/B 95 - 90 very good
  • B 90 - 80 good
  • B/C 80 -75 average
  • C 75 -70 fair,
  • GRADS pass
  • D 70 65 so la la,
  • UNDERGRADS pass
  • GRADS fail
  • ltD FAIL

13
Advanced Tissue Engineering III, Spring 2005
  • Course Policies
  • General Policies
  • in accordance with university regulations
  • Attendance
  • Mandatory for both lecture and recitations,
    sign-up sheets
  • Exams
  • Midterm and Final Exams papers/proposals and
    peer-reviews due on dates stated
  • Team papers with individual contributions clearly
    marked
  • Students will be graded based on individual
    performance and as team members and as
    (individual) peer-reviewers
  • Grading Disputes
  • Must be settled with instructor within 1 week
    after grading

14
Advanced Tissue Sciences and Engineering
  • http//www.advancedtissue.com/
  • You have reached the web site for the ATS
    Liquidating Trust.
  • We intend for this site to be a continuing source
    of news and information on the activities of the
    Trust.

15
  • Tissue engineering demonstrates enormous
    potential for improving human health.
  • While there is an extensive body of literature
    discussing the state of the art of tissue
    engineering, the majority of this literature is
    descriptive and does little to address the
    principles that govern the success or failure of
    an engineered tissue.
  • This course will explore principles of tissue
    engineering, drawing upon diverse fields such as
    developmental biology, immunology, cell biology,
    physiology, transport phenomena, material
    science, and polymer chemistry.
  • Current and developing methods of tissue
    engineering as well as specific applications will
    be discussed in the context of these principles.

16
Tissue Engineering
  • Biotechnological Platform for
  • Enhanced Drug Screening
  • Food Production
  • Art

17
Principles in Tissue EngineeringUNC
  • The course will include a detailed knowledge of
    representative tissues and their structures and
    function, biomaterials used to fabricate tissue
    engineered devices, fabrication methods, cell
    culture and cell growth conditions, immunology
    and host responses to foreign bodies, matrix
    anabolism and catabolism, host-device
    interfacing, microelectronics, biotechnology
    development, intellectual property, animal model
    testing, human testing good laboratory practices,
    FDA regulations.
  • At least one plant trip to a device or
    fabrication plant is planned.
  • Guest lecturers, expert in the field, will give
    lectures.
  • The course will include 3 one hour lectures per
    week or the equivalent. Grades will be computed
    based on results of two exams, a paper, quizzes,
    attendance and a final exam

18
Tissue Engineering
  • Biotechnological Platform for Enhanced Drug
    Screening

19
Tissue Engineering and Art
  • http//www.tca.uwa.edu.au/
  • http//www.tca.uwa.edu.au/ars/timebased/1.html
  • http//www.tca.uwa.edu.au/ars/timebased/2.html

20
Advanced Tissue Engineering ?
  • Growing a full scale human ear using tissue
    engineering techniques is still somewhat
    problematic.
  • The engineered cartilage cells seem to loose
    their structural integrity and the whole form
    tend to collapse.

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Some Relevant URLs
  • Cell/tissue culture automation
  • http//www.automationpartnership.com/a/robotic-cel
    l-culture-gp.htm
  • Search for tissue engineering
  • http//www.dmoz.org/,
  • http//search.dmoz.org/cgi-bin/search?search22ti
    ssueengineering22
  • Art and Tissue Culture/Engineering
  • http//www.tca.uwa.edu.au/
  • http//www.symbiotica.uwa.edu.au/
  • Image analysis for TE
  • http//www.tissueinformatics.com/
  • Vacanti-Lab MIT/Harvard
  • http//www.mgh.harvard.edu/depts/tissue/projects/m
    ains/amain.html
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