CLA-1/SR-BI protein may promote cholesterol removal from peripheral cells - PowerPoint PPT Presentation

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CLA-1/SR-BI protein may promote cholesterol removal from peripheral cells

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CLA-1 expression is regulated by PPARa activators. in differentiated human macrophages. PPARa activators induce cholesterol efflux. and reverse cholesterol transport ... – PowerPoint PPT presentation

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Title: CLA-1/SR-BI protein may promote cholesterol removal from peripheral cells


1
CLA-1/SR-BI protein may promote
cholesterolremoval from peripheral cells
2
CLA-1 expression is regulated by PPARa
activatorsin differentiated human macrophages
3
PPARa activators induce cholesterol effluxand
reverse cholesterol transport
4
PPARs in the vascular wall
5
Mechanisms of transrepression by PPARa
6
The transcription factor NFkBa key role in the
inflammatory response
7
Model of NFkB signal pathway inhibition by PPARa
activators
8
PPARa activated by fibrates inhibits
IL-1binduced expression of COX-2 in SMC
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