Lamotrigine vs Lithium vs Placebo: Time to Intervention for a Mood Episode

1
Lamotrigine vs Lithium vs Placebo Time to
Intervention for a Mood Episode
1
Li vs PBO, P 0.029 LTG vs PBO, P 0.029 LTG
vs Li, P 0.915
0.9
0.8
0.7
Median 24 weeks
0.6
Median 29 weeks
Survival Estimate
0.5
Li (n 46)
0.4
LTG (n 59)
0.3
PBO (n 70)
0.2
0.1
0
60
70
0
10
20
30
40
50
Week
LTG lamotrigine 100 to 400 mg daily Li
lithium 0.8-1.1 mEq/L PBO placebo
Bowden CL et al. Arch Gen Psychiatry.
200360392-400.