Technical Overview Relovox Rx Acne Therapy A Revolutionary Oxygen Therapy

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Technical Overview Relovox Rx (Acne Therapy) (A
Revolutionary Oxygen Therapy)

• Dr. Pankaj Modi, PhD, MD
• Founder and President

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Presentation Goals

• Introduction to Relovox Technologies
• Goals
• Micelle Drug Delivery System
• Clinical Studies and Results
• Q and A

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Acne Therapy and Market Potential

• Acne is a disorder resulting from the action of
  hormones on the skin's oil glands (sebaceous
  glands)
• It leads to plugged pores and outbreaks of
  lesions commonly called pimples or zits.
• Acne lesions usually occur on the face, neck,
  back, chest, and shoulders.
• Nearly 30 million people in the United States
  have acne, making it the most common skin
  disease.
• People of all races and ages get acne.
• It is most common in adolescents and young
  adults.
• Nearly 85 percent of people between the ages of
  12 and 24 develop the disorder.
• The total market size for the treatment of skin
  related problems exceeds more than 20 billions
  and growing
• Everyone wants to improve their appearance and
  look young.

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Topical Antibacterial Agents

• Current formulations on the Market today are
  Harsh on the skin and damaging
• Despite their claims, they do not remove Acne
  and Scars effectively
• They contain sulfur and salicylic acid and
  phenols
• They leave white residue on the skin upon drying
  as these ingredients forms insoluble formulations
• They cause irritation, burning and redness
• Most formulations leaves skin dry and creates
  roughness

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Goals of Acne Therapy (Relovox-Rx)

• Relieving discomfort and pain
• Preventing pitting or scarring
• Limiting psychosocial distress
• To quickly provide highest concentration of
  OXYGEN to kill bacteria and helps unplug the
  pores
• Canadian DIN Approved Products
• (US and World) Patent Protected Technology

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Micellar Formulation Novel Drug Delivery
Technology

• This novel delivery system enables insoluble
  active pharmaceuticals to be solubilized into an
  aqueous formulation.
• The micelle nanotechnology is patented
  Technology in North America and Europe and
  pending applications relating to a range of
  compounds.
• Micelle nanotechnology entraps hydrophobic
  (water insoluble) drug compounds (e.g. benzoyl
  peroxide) inside minute particles built up from
  absorption enhancer and biological detergent
  molecules.
• This formulation technique potentially delivers
  effective concentrations of drugs which would
  normally be insoluble in aqueous based
  formulations and difficult to deliver and
  absorbed through the skin.
• The micelles also protect the entrapped drug
  from hydrolysis by enzymes or from pH
  environments and thus enable more active
  medication to be delivered to their site of
  action.

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Advantages of Micellar Technology

• Micelles are multi layered nano-particles drug
  delivery technologies
• Composed of FDA approved excipients
  (ingredients)
• Technology formulation, process as well as a
  delivery technology
• Technology is highly adaptable to most high
  molecular weight drugs, proteins, peptides and
  insoluble hydrophobic molecules
• Capable of delivering more than one therapeutic
  agent at a time
• The platform technology can also be extended to
  developed other topical pain management therapy
  e.g., fast acting topical anesthetics, vaccines
  delivery, wound healing formulations, etc
• Offers high market value by featuring maximum
  functionality at minimum system complexity and
  cost
• The technology is easily scalable to any size
  without any complex new equipments need

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Unique Formulation Properties

• Relovox Formulation is an advanced drug
  delivery system that provides Combination Therapy
  acne management system
• it combines prescription-grade ingredients in a
  system that works together to heal and prevent
  acne.
• This unique acne fighting system combines finely
  milled medical actives combined other special
  formulation.
• These ingredients gently exfoliate your skin,
  unplug your pores, attack acne-causing bacteria,
  and soothe inflammation.
• This Novel combination therapy uses several
  different medicines in one system to heal the
  pimples, acne, blemishes
• It helps reduced the formation of age spots, and
  hyper pigmentations by improving the skin
  appearance in 2-4 weeks instead of 8-12 weeks.

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• How it works
• Helps to normalize sebum secretion and clear
  clogged follicles, one of the most aggressive
  causes of breakouts.
• The Acne Formulations with unique trans-dermal
  delivery properties provide for optimal
  absorption of nutrients and astringents.
• It quickly penetrates into the deep layers of
  the dermis where healing and regeneration occur-
  allowing for your skin's miraculous return.
• Highly recommended for body acne (cystic
  especially) as well as a spot treatment for the
  face.
• Very effective in absorbing excess oil, opening
  clogged pores, and reducing the severity of a
  breakout.

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Insoluble vs Novel Soluble Relovox Formulation
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• 5 Simple steps to treat Acne and acne prone skin
• Step-1 Renewing Cleanser (liquid or pad)
• This unique oil-free formula contains smooth,
  tiny grains to gently exfoliate dead skin cells
  and other impurities
• Step-2 Fast Acting 5 minute Mask
• The Acne Mask is specifically formulated to use
  on inflamed and acne troubled skin. The Full Face
  Mask will limit breakouts by decongesting the
  skin pores and stabilizing the oil production.
  It is Formulated with natural combination of
  French Green Clay, Great Barrier Reef Sea
  Minerals, Aloe Vera and Vitamin B5 is perfect for
  clearing problem skin.
• Step-3 Revitalizing Toner
• This refreshing, alcohol-free toner removes dead
  skin cells, unplugs pores and helps remove excess
  oil so your skin looks and feels refreshed.
  Soothing botanical agents gently balance your
  skin tone.
• Step-4 Repairing Lotion
• Light, oil-free lotion contains finely milled
  prescription-grade medicinal agents to heal
  blackheads and blemishes and helps prevent future
  breakouts. The advanced delivery system in
  Repairing Lotion is soothing and safe for entire
  face
• Step-5 Acne Scar Removing Lotion or Cream
• This novel formulation helps by encouraging
  collagen production in the skin. It helps improve
  overall skin tone and luster and improves the
  appearance of fine lines. It is made of a
  combination of collagen and Hyaluronic acid. It
  works by forming the connective tissues in the
  form of collagen around the scars and acne
  infected area, which gives volume to the skin and
  corrects the wrinkle or depressed scar.

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Packaging Option 1
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Packaging Option 2
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Relovox 5 Steps Kit

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Human Clinical studies
Objective To assess acne improvement and
tolerability of the solubilized benzoyl peroxide
topical formulation of Example 1 (at 3.5 benzoyl
peroxide) during 12 weeks of treatment in
comparison to a non-medicated cream control.
Participants  A total of 99 patients aged 12
to 39 years with facial acne were enrolled in the
study. Intervention  The study was randomized,
and controlled by using a non-medicated (vehicle)
cream identical to the base of the active cream.
The medication samples were distributed in
identical boxed pairs of 30 g tubes labeled
morning application and evening application.
The dosage of cream per application was
approximately 0.6 g, described and demonstrated
to patients as a pea-sized amount.

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Before and After Photographs

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Conclusions

• Trans-dermal delivery system optimizes
  absorption of active ingredients
• Supports natural protective mantle of the skin
• Prevents follicular clogging
• Normalizes secretion of sebum
• Draws out impurities
• Limits growth of causative bacterial agents
• Medicinal and Botanical extracts are effective
  against hormonal breakouts by reducing the oily
  and excessive hormonal breakouts,
• Regular use dramatically reduced the visible
  signs of aging, fine lines, wrinkles, age spots,
  and sagging skin.
• Treated skin gradually appeared firmer and
  smoother with improved texture, tone and overall
  radiance.
• These formulations are extremely well tolerated
  and can be used by men and women without fear of
  troublesome skin reactions such as sunlight
  sensitivity.

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Thank You